Biology:TFB2M
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Dimethyladenosine transferase 2; transcription factor B2, mitochondrial is an enzyme that in humans is encoded by the TFB2M gene.[1]
This protein is a transcription initiation factor for the mitochondrial RNA polymerase, POLRMT. Its paralog TFB1M can perform a similar function, but only in vitro.[2]
References
- ↑ "Entrez Gene: TFB2M transcription factor B2, mitochondrial". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64216.
- ↑ Hillen, HS; Morozov, YI; Sarfallah, A; Temiakov, D; Cramer, P (16 November 2017). "Structural Basis of Mitochondrial Transcription Initiation.". Cell 171 (5): 1072–1081.e10. doi:10.1016/j.cell.2017.10.036. PMID 29149603.
Further reading
- "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.". Nat. Genet. 31 (3): 289–94. 2002. doi:10.1038/ng909. PMID 12068295.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2.". Mamm. Genome 14 (1): 1–6. 2003. doi:10.1007/s00335-002-2218-z. PMID 12532263.
- "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity.". Mol. Cell. Biol. 23 (16): 5816–24. 2003. doi:10.1128/MCB.23.16.5816-5824.2003. PMID 12897151.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells.". EMBO J. 23 (23): 4606–14. 2005. doi:10.1038/sj.emboj.7600465. PMID 15526033.
- "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators.". Mol. Cell. Biol. 25 (4): 1354–66. 2005. doi:10.1128/MCB.25.4.1354-1366.2005. PMID 15684387.
- "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
- "Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2.". J. Mol. Evol. 63 (5): 707–17. 2007. doi:10.1007/s00239-006-0075-1. PMID 17031457.
- "Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression.". Nucleic Acids Res. 35 (12): 4042–54. 2007. doi:10.1093/nar/gkm424. PMID 17557812.
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