Biology:TFB1M
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Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial is a mitochondrial enzyme that in is encoded by the TFB1M gene.[1][2][3]
TFB1M is a mitochondrial methyltransferase, which uses S-adenosyl methionine to dimethylate two highly conserved adenosine residues at the 3'-end of the mitochondrial 12S rRNA thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.[2][4][5]
Additionally, TFB1M has been demonstrated to stimulate transcription from promoter templates in an in vitro system containing recombinant mitochondrial RNA polymerase and TFAM.[6] There are no experimental data demonstrating that this function occurs in vivo; the paralogous TFB2M is more specific for this role.[7]
Interactions
TFB1M has been shown to interact with TFAM.[8]
References
- ↑ "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res 10 (5): 703–13. Aug 2000. doi:10.1101/gr.10.5.703. PMID 10810093.
- ↑ 2.0 2.1 "A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine". Mol Cell Biol 22 (4): 1116–25. Jan 2002. doi:10.1128/MCB.22.4.1116-1125.2002. PMID 11809803.
- ↑ "Entrez Gene: TFB1M transcription factor B1, mitochondrial". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51106.
- ↑ "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.". Nat. Genet. 31 (3): 289–94. 2002. doi:10.1038/ng909. PMID 12068295.
- ↑ Metodiev MD; Lesko N; Park CB; Camara Y.; Shi Y.; Wibom R.; Hultenby K.; Gustafsson CM et al. (Apr 2009). "Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome". Cell Metab. 9 (4): 386–97. doi:10.1016/j.cmet.2009.03.001. PMID 19356719.
- ↑ "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.". Nat. Genet. 31 (3): 289–94. 2002. doi:10.1038/ng909. PMID 12068295.
- ↑ Hillen, HS; Morozov, YI; Sarfallah, A; Temiakov, D; Cramer, P (16 November 2017). "Structural Basis of Mitochondrial Transcription Initiation.". Cell 171 (5): 1072–1081.e10. doi:10.1016/j.cell.2017.10.036. PMID 29149603.
- ↑ McCulloch, Vicki; Shadel Gerald S (Aug 2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity". Mol. Cell. Biol. 23 (16): 5816–24. doi:10.1128/MCB.23.16.5816-5824.2003. ISSN 0270-7306. PMID 12897151.
Further reading
- "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.". Nat. Genet. 31 (3): 289–94. 2002. doi:10.1038/ng909. PMID 12068295.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop.". Nat. Genet. 33 (1): 23–4. 2003. doi:10.1038/ng1064. PMID 12496758.
- "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2.". Mamm. Genome 14 (1): 1–6. 2003. doi:10.1007/s00335-002-2218-z. PMID 12532263.
- "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity.". Mol. Cell. Biol. 23 (16): 5816–24. 2003. doi:10.1128/MCB.23.16.5816-5824.2003. PMID 12897151.
- "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. 2003. doi:10.1038/nature02055. PMID 14574404. Bibcode: 2003Natur.425..805M.
- "Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation.". Mol. Genet. Metab. 82 (1): 27–32. 2004. doi:10.1016/j.ymgme.2004.01.020. PMID 15110318.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators.". Mol. Cell. Biol. 25 (4): 1354–66. 2005. doi:10.1128/MCB.25.4.1354-1366.2005. PMID 15684387.
- "Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression.". Nucleic Acids Res. 35 (12): 4042–54. 2007. doi:10.1093/nar/gkm424. PMID 17557812.
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