Chemistry:Pleuran
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| (C6H10O5)x | |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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Pleuran is an insoluble polysaccharide (β-(1,3/1,6)-D-glucan), isolated from Pleurotus ostreatus.[1]
Pleuran belongs to a group of glucose polymers commonly called beta-glucans demonstrating biological response modifier properties. These immunomodulating properties render the host more resistant to infections and neoplasms.[2]
In a study published in December 2010, pleuran demonstrated to have a protective effect against exercise-induced suppression of immune cell activity (NK cells) in subjects taking 100 mg per day.[3]
In another study published in 2011, pleuran reduced the incidence of upper respiratory tract infections and increased the number of circulating NK cells.[4]
Pleuran is also being studied as a potential immunologic adjuvant.[5]
References
- ↑ "Polysaccharides of Pleurotus ostreatus: Isolation and structure of pleuran, an alkali-insoluble β-glucan". Carbohydrate Polymers (Elsevier) 24 (2): 107–111. 1994. doi:10.1016/0144-8617(94)90019-1.
- ↑ Di Luzio, NR (1985). "Update on the immunomodulating activities of glucans". Springer Seminars in Immunopathology (Germany: Springer Verlag) 8 (4): 387–400. doi:10.1007/BF01857392. PMID 4089757.
- ↑ Bobovčák, M; Kuniaková, R, Gabriž, J, Majtán, J (December 2010). "Effect of Pleuran (β-glucan from Pleurotus ostreatus) supplementation on cellular immune response after intensive exercise in elite athletes.". Applied Physiology, Nutrition, and Metabolism 35 (6): 755–62. doi:10.1139/h10-070. PMID 21164546.
- ↑ Bergendiova, K; Tibenska, E, Majtan, J (2011-01-20). "Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes.". European Journal of Applied Physiology 111 (9): 2033–40. doi:10.1007/s00421-011-1837-z. PMID 21249381.
- ↑ "A Compendium of Vaccine Adjuvants and Excipients". Pharmaceutical Biotechnology. 2nd ed (National Institute of Allergy and Infectious Diseases) 6: 141–228. 1998. doi:10.1007/978-1-4615-1823-5_7. ISBN 978-1-4613-5737-7. PMID 7551218. http://www.niaid.nih.gov/hivvaccines/pdf/compendium.pdf. Retrieved 2008-05-08.
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