Biography:Donna R. Maglott

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Short description: American geneticist
Donna R. Maglott
Alma materUniversity of Michigan
Scientific career
InstitutionsNational Center for Biotechnology Information
ThesisThe structure and function of the 50S ribosome of Escherichia coli (1970)

Donna R. Maglott is a staff scientist at the National Center for Biotechnology Information known for her research on large-scale genomics projects, including the mouse genome and development of databases required for genomics research.

Education and career

Maglott earned her Ph.D. in 1970 from the University of Michigan where she worked on the 50S ribosome in the bacterium Escherichia coli.[1] She held an academic position at Howard University;[when?] and then moved to the American Type Culture Center in 1986 where she began establishing databases needed for genomic research.[2][3] She started at the National Center for Biotechnology Information (NCBI) in 1998.[4]

Research

While at Howard University, Maglott worked on protein synthesis during early development of sea urchins.[5][6] At ATCC, she worked on repositories holding clone and genomic information[7][8] and began research using genomic tools to investigate information on human chromosomes.[9][10] In 2000, Maglott worked with Kim D. Pruitt to introduce RefSeq, a web-based resource for gene-based information that is hosted by NCBI[11][12] and has been updated over the years.[13][14] She has also been involved in the development of other databases at NCBI including Entrez Gene,[15][16] ClinVar,[17][18] STS markers, Conserved CoDing Sequences (CCDS), Map Viewer, RefSeqGene, the NIH Genetic Testing Registry (GTR), MedGen, and ClinVar.[4] Large-scale genomics projects that Margott has worked on include the rat genome database,[19] and the mouse genome[20][21] and transcriptome.[22] In 2006, Maglott was a part of the team analyzing the genome of the sea urchin, Strongylocentrotus purpuratus, which was the first genome obtained for a motile marine invertebrate.[23][24]

Selected publications

References

  1. ↑ Maglott, Donna Rae Schneider (1970). The structure and function of the 50S ribosome of Escherichia coli (Thesis). Ann Arbor - Mich. OCLC 633231185.
  2. ↑ "Center for Bioinformatics and Computational Biology". 2006. http://www.cbcb.umd.edu/seminars/2006.09-12.shtml. 
  3. ↑ "Donna Maglott, PhD - ClinGen | Clinical Genome Resource". 2017-07-10. https://clinicalgenome.org/about/people/staff/donna-maglott-phd/. 
  4. ↑ 4.0 4.1 "Human Variome Project". http://www.humanvariomeproject.org. 
  5. ↑ Maglott, D.R. (1985). "Dissociation of cells from sea urchin embryos alters the synthesis of actins and other proteins" (in en). Cell Differentiation 17 (1): 29–43. doi:10.1016/0045-6039(85)90535-4. PMID 3875415. https://linkinghub.elsevier.com/retrieve/pii/0045603985905354. 
  6. ↑ Maglott, D.R. (1985). "Two-dimensional electrophoretic analysis of major phosphoproteins of the sea urchin, Arbacia punctulata" (in en). Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 80 (3): 513–516. doi:10.1016/0305-0491(85)90282-2. PMID 4006443. https://linkinghub.elsevier.com/retrieve/pii/0305049185902822. 
  7. ↑ Maglott, Donna R.; Nierman, William C. (1990-11-01). "Clone and genomic repositories at the American Type Culture Collection" (in en). Genomics 8 (3): 601–605. doi:10.1016/0888-7543(90)90054-X. ISSN 0888-7543. PMID 1981058. https://dx.doi.org/10.1016/0888-7543%2890%2990054-X. 
  8. ↑ Maglott, Donna R.; Nierman, William C. (1991). "Mammalian probes and libraries at the ATCC" (in en). Mammalian Genome 1 (1): 59–64. doi:10.1007/BF00350848. ISSN 0938-8990. PMID 1794047. http://link.springer.com/10.1007/BF00350848. 
  9. ↑ Scott Durkin, A.; Maglott, Donna R.; Nierman, William C. (1992-11-01). "Chromosomal assignment of 38 human brain expressed sequence tags (ESTs) by analyzing fluorescently labeled PCR products from hybrid cell panels" (in en). Genomics 14 (3): 808–810. doi:10.1016/S0888-7543(05)80194-6. ISSN 0888-7543. PMID 1427913. https://www.sciencedirect.com/science/article/pii/S0888754305801946. 
  10. ↑ Schmidt, Valentina A.; Nierman, William C.; Maglott, Donna R.; Cupit, Lisa D.; Moskowitz, Keith A.; Wainer, Jean Ann; Bahou, Wadie F. (1998). "The Human Proteinase-activated Receptor-3 (PAR-3) Gene". Journal of Biological Chemistry 273 (24): 15061–15068. doi:10.1074/jbc.273.24.15061. ISSN 0021-9258. PMID 9614115. 
  11. ↑ Maglott, D. R. (2000-01-01). "NCBI's LocusLink and RefSeq". Nucleic Acids Research 28 (1): 126–128. doi:10.1093/nar/28.1.126. PMID 10592200. 
  12. ↑ Pruitt, Kim D.; Katz, Kenneth S.; Sicotte, Hugues; Maglott, Donna R. (2000). "Introducing RefSeq and LocusLink: curated human genome resources at the NCBI" (in en). Trends in Genetics 16 (1): 44–47. doi:10.1016/S0168-9525(99)01882-X. PMID 10637631. https://linkinghub.elsevier.com/retrieve/pii/S016895259901882X. 
  13. ↑ Pruitt, K. D. (2001-01-01). "RefSeq and LocusLink: NCBI gene-centered resources". Nucleic Acids Research 29 (1): 137–140. doi:10.1093/nar/29.1.137. PMID 11125071. 
  14. ↑ Pruitt, K. D.; Tatusova, T.; Maglott, D. R. (2007-01-03). "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins" (in en). Nucleic Acids Research 35 (Database): D61–D65. doi:10.1093/nar/gkl842. ISSN 0305-1048. PMID 17130148. 
  15. ↑ Maglott, D. (2004-12-17). "Entrez Gene: gene-centered information at NCBI" (in en). Nucleic Acids Research 33 (Database issue): D54–D58. doi:10.1093/nar/gki031. ISSN 1362-4962. PMID 15608257. 
  16. ↑ Maglott, D.; Ostell, J.; Pruitt, K. D.; Tatusova, T. (2011-01-01). "Entrez Gene: gene-centered information at NCBI" (in en). Nucleic Acids Research 39 (Database): D52–D57. doi:10.1093/nar/gkq1237. ISSN 0305-1048. PMID 21115458. 
  17. ↑ Landrum, Melissa J; Lee, Jennifer M; Benson, Mark; Brown, Garth R; Chao, Chen; Chitipiralla, Shanmuga; Gu, Baoshan; Hart, Jennifer et al. (2018-01-04). "ClinVar: improving access to variant interpretations and supporting evidence" (in en). Nucleic Acids Research 46 (D1): D1062–D1067. doi:10.1093/nar/gkx1153. ISSN 0305-1048. PMID 29165669. PMC 5753237. http://academic.oup.com/nar/article/46/D1/D1062/4641904. 
  18. ↑ Landrum, Melissa J.; Lee, Jennifer M.; Riley, George R.; Jang, Wonhee; Rubinstein, Wendy S.; Church, Deanna M.; Maglott, Donna R. (2014). "ClinVar: public archive of relationships among sequence variation and human phenotype" (in en). Nucleic Acids Research 42 (D1): D980–D985. doi:10.1093/nar/gkt1113. ISSN 0305-1048. PMID 24234437. 
  19. ↑ Twigger, S. (2002-01-01). "Rat Genome Database (RGD): mapping disease onto the genome". Nucleic Acids Research 30 (1): 125–128. doi:10.1093/nar/30.1.125. PMID 11752273. 
  20. ↑ Mouse Genome Sequencing Consortium (2002). "Initial sequencing and comparative analysis of the mouse genome" (in en). Nature 420 (6915): 520–562. doi:10.1038/nature01262. ISSN 0028-0836. PMID 12466850. Bibcode: 2002Natur.420..520W. 
  21. ↑ Hudson, Thomas J.; Church, Deanna M.; Greenaway, Simon; Nguyen, Huy; Cook, April; Steen, Robert G.; Van Etten, William J.; Castle, Andrew B. et al. (2001). "A radiation hybrid map of mouse genes" (in en). Nature Genetics 29 (2): 201–205. doi:10.1038/ng1001-201. ISSN 1061-4036. PMID 11586302. http://www.nature.com/articles/ng1001-201. 
  22. ↑ The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I & II Team* (2002). "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs" (in en). Nature 420 (6915): 563–573. doi:10.1038/nature01266. ISSN 0028-0836. PMID 12466851. Bibcode: 2002Natur.420..563O. 
  23. ↑ Sea Urchin Genome Sequencing Consortium; Sodergren, E.; Weinstock, G. M.; Davidson, E. H; Cameron, R. A.; Gibbs, R. A.; Angerer, R. C.; Angerer, L. M. et al. (2006-11-10). "The Genome of the Sea Urchin Strongylocentrotus purpuratus" (in en). Science 314 (5801): 941–952. doi:10.1126/science.1133609. ISSN 0036-8075. PMID 17095691. Bibcode: 2006Sci...314..941S. 
  24. ↑ Livingston, B.T.; Killian, C.E.; Wilt, F.; Cameron, A.; Landrum, M.J.; Ermolaeva, O.; Sapojnikov, V.; Maglott, D.R. et al. (2006). "A genome-wide analysis of biomineralization-related proteins in the sea urchin Strongylocentrotus purpuratus" (in en). Developmental Biology 300 (1): 335–348. doi:10.1016/j.ydbio.2006.07.047. PMID 16987510. 



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