Biography:Edward C. Holmes

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Eddie Holmes

Edward Holmes Royal Society.jpg
Eddie Holmes at the Royal Society admissions day in July 2017
Born
Edward Charles Holmes

(1965-02-26) 26 February 1965 (age 59)[1]
Alma materUniversity of London (BSc)
University of Cambridge (PhD)
Known forMolecular Evolution: A Phylogenetic Approach[2]
Awards
Scientific career
FieldsVirology
Evolutionary biology[4]
InstitutionsUniversity of Sydney
Pennsylvania State University
University of Oxford
University of Edinburgh
University of California, Davis[3]
ThesisPattern and Process in the Molecular Evolution of the Order Primates (1990)
Academic advisorsAdrian Friday[1]
InfluencesPaul Harvey
Websitesydney.edu.au/science/people/edward.holmes.php

Edward Charles Holmes FRS FAA[5] (born 1965, UK)[1] is an evolutionary biologist and virologist, and since 2012 an National Health and Medical Research Council (NHMRC) Australia Fellow and professor at the University of Sydney.[4][6][7]

Education

Holmes was educated at University College London where he received a Bachelor of Science degree in Anthropology in 1986.[1] He then moved to the University of Cambridge where he was awarded a Doctor of Philosophy degree in Zoology in 1990[8][1] for research on molecular evolution in primates supervised by Adrian Friday.[1]

Research and career

Holmes has used genomic and phylogenetic approaches to reveal the major mechanisms of virus evolution and determined the genetic and epidemiological processes that explain how viruses jump species boundaries and spread in new hosts.[5] His work has revealed the origin, evolution and molecular epidemiology of important human pathogens including Hepatitis C,[9][10] influenza,[11][12] HIV[13] and dengue,[14] and enabled more accurate assessments of what types of virus are most likely to emerge in human populations and whether they will evolve human-to-human transmission.[5] His recent research has provided fundamental insights into the breadth and biodiversity of the viral world.[5]

Holmes wrote The Evolution and Emergence of RNA Viruses[15] part of the Oxford Series in Ecology and Evolution edited by Paul H. Harvey and Robert M. May. He also co-authored the textbook Molecular Evolution: A Phylogenetic Approach with Rod Page.[2] Since 1994 he has supervised 26 doctoral students[1] including Marcus Gilbert,[16] Christopher Woelk,[17] Polly Walker,[18] Charles Edwards,[19] Sally Twiddy,[20] Patricia Davis,[21] Michael Worobey,[22] Gareth Jenkins,[23] María Álvarez,[24] Andrew Jackson,[25] and Angela Brueggemann.[26]

His research has been funded by the Royal Society,[5] the UK Biotechnology and Biological Sciences Research Council (BBSRC), Canadian Natural Sciences and Engineering Research Council (NSERC), Rhodes Trust, Wellcome Trust, United States National Institutes of Health (NIH), National Science Foundation (NSF) and Australian National Health and Medical Research Council (NHMRC).[1][3]

Before moving to Sydney in 2012, Holmes held academic appointments at various Universities in the UK and USA including:

1990–1991 University of California, Davis[1], postdoctoral researcher supervised by Charles H. Langley.
1991–1993 University of Edinburgh[1], postdoc funded by the UK Medical Research Council (MRC).[1][9]
1993–2004 University of Oxford[1] where he was a Fellow of New College, Oxford and St Catherine's College, Oxford
2005–2012 Pennsylvania State University, Full Professor of Biology[1]

Awards and honours

Holmes was elected a Fellow of the Australian Academy of Science (FAA) in 2015 and a Fellow of the Royal Society (FRS) in 2017.[5] He was awarded the Scientific Medal, Zoological Society of London in 2003.[1]

Personal life

Holmes lists his recreations as Whale Beach, New South Wales, electric guitars and Aston Villa Football Club.[27]

References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 Holmes, Eddie (2017). "Edward C. Holmes – Curriculum Vitae". University of Sydney. Archived from the original on 8 August 2017. https://web.archive.org/web/20170808114429/http://api.profiles.sydney.edu.au/AcademicProfiles/profile/resource?urlid=edward.holmes&type=cv. 
  2. 2.0 2.1 Page, Roderic D. M.; Holmes, Edward C. (1998). Molecular evolution : a phylogenetic approach. Oxford: Blackwell Science. ISBN 9780865428898. OCLC 47011609. https://www.worldcat.org/oclc/47011609. 
  3. 3.0 3.1 3.2 3.3 Edward C. Holmes Entry at ORCID
  4. 4.0 4.1 {{Google Scholar id}} template missing ID and not present in Wikidata.
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Anon (2017). "Professor Edward Holmes FRS". London: Royal Society. Archived from the original on 11 May 2017. https://web.archive.org/web/20170511093753/https://royalsociety.org/people/edward-holmes-13395/.  One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --"Royal Society Terms, conditions and policies". Archived from the original on 11 November 2016. https://web.archive.org/web/20161111170346/https://royalsociety.org/about-us/terms-conditions-policies/. Retrieved 9 March 2016. 
  6. Edward C. Holmes publications indexed by the Scopus bibliographic database. (Subscription content?)
  7. Edward C. Holmes publications from Europe PubMed Central
  8. Holmes, Edward Charles (1989). Pattern and process in the molecular evolution of the order primates. proquest.com (PhD thesis). University of Cambridge. OCLC 53489363. EThOS uk.bl.ethos.317751. Italic or bold markup not allowed in: |website= (help)
  9. 9.0 9.1 Simmonds, Peter; Alberti, Alfredo; Alter, Harvey J.; Bonino, Ferruccio; Bradley, Daniel W.; Brechot, Christian; Brouwer, Johannes T.; Chan, Shiu-Wan et al. (1994). "A proposed system for the nomenclature of hepatitis C viral genotypes". Hepatology 19 (5): 1321–1324. doi:10.1002/hep.1840190538. ISSN 02709139. 
  10. Simmonds, P.; Irvine, B.; Yap, P. L.; Kolberg, J.; Chan, S.-W.; Cha, T.-A.; Beall, E.; Urdea, M. S. et al. (1993). "Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region". Journal of General Virology 74 (11): 2391–2399. doi:10.1099/0022-1317-74-11-2391. ISSN 0022-1317. PMID 8245854. 
  11. Subbarao, Kanta; Tong, Suxiang; Zhu, Xueyong; Li, Yan; Shi, Mang; Zhang, Jing; Bourgeois, Melissa; Yang, Hua et al. (2013). "New World Bats Harbor Diverse Influenza A Viruses". PLOS Pathogens 9 (10): e1003657. doi:10.1371/journal.ppat.1003657. ISSN 1553-7374. PMID 24130481.  open access
  12. Rambaut, Andrew; Pybus, Oliver G.; Nelson, Martha I.; Viboud, Cecile; Taubenberger, Jeffery K.; Holmes, Edward C.. "The genomic and epidemiological dynamics of human influenza A virus". Nature 453 (7195): 615–619. doi:10.1038/nature06945. PMID 18418375.  closed access
  13. Leslie, A J; Pfafferott, K J; Chetty, P; Draenert, R; Addo, M M; Feeney, M; Tang, Y; Holmes, E C et al. (2004). "HIV evolution: CTL escape mutation and reversion after transmission". Nature Medicine 10 (3): 282–289. doi:10.1038/nm992. ISSN 1078-8956. PMID 14770175. 
  14. Holmes, E; Twiddy, S (2003). "The origin, emergence and evolutionary genetics of dengue virus". Infection, Genetics and Evolution 3 (1): 19–28. doi:10.1016/S1567-1348(03)00004-2. ISSN 15671348.  (Subscription content?)
  15. Holmes, Edward C. (2009). The Evolution and Emergence of RNA Viruses. Oxford Series in Ecology and Evolution. Oxford, New York: Oxford University Press. ISBN 9780199211135. https://global.oup.com/academic/product/the-evolution-and-emergence-of-rna-viruses-9780199211135. 
  16. Gilbert, Marcus Thomas Pius (2003). An assessment of the use of human samples in ancient DNA studies (DPhil thesis). University of Oxford. OCLC 61188157. EThOS uk.bl.ethos.404119. open access
  17. Woelk, Christopher Harron. (2002). The adaptive evolution of emergent and endemic viruses (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.249496.
  18. Walker, Polly Rose (2006). Evolution and infectivity of HIV-1 subtype C viruses (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.442985.
  19. Edwards, Charles T. T. (2004). The evolution of HIV-1 during transmission and chronic infection (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.410560.
  20. Twiddy, Sally Susanna (2002). The molecular epidemiology and evolution of dengue virus (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.269490.
  21. Davis, Patricia (2005). The molecular evolution and genetic epidemiology of lyssaviruses (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.433259.
  22. Worobey, Michael (2002). The occurrence and impact of viral recombination (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.249612.
  23. Jenkins, Gareth Mark (2001). Determinants of the molecular evolution of RNA viruses (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.365413.
  24. Allvarez, Marila C. Armesto (2004). Molecular studies of tick-borne encephalitis virus (DPhil thesis). University of Oxford. OCLC 74119965. EThOS uk.bl.ethos.413476.
  25. Jackson, Andrew (2004). The application of phylogenetic reconciliation to the study of coevolution (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.403742.
  26. Brueggemann, Angela Beth (2004). Exploring the population biology and invasive disease potential of Streptococcus pneumoniae (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.400557.
  27. Fallon, Bailey (2015). "Meet our Editors: An interview with Edward Holmes". Archived from the original on 19 November 2016. https://web.archive.org/web/20161119062029/https://blogs.royalsociety.org/publishing/meet-our-editors-an-interview-with-edward-holmes/.