Biography:Jannie Borst
Jannie G. Keyser-Borst is a Dutch cancer immunologist. She became Professor at Leiden University on 16 January 2019 [1] At the Leiden University Medical Center she currently runs a research group investigating the regulation of the T cell response [2]
Education and career
In 1980 she received her Master's degree in biology with chemistry at Leiden University. For the main part of her PhD she worked at the Dana–Farber Cancer Institute, Harvard Medical School in Boston, supervised by Prof. Dr. Cox P Terhorst. During this time she unraveled the structure of the CD3/T cell complex. After graduation she worked with Immunologists Dr Jan E de Vries and Dr Hergen Spits in the Netherlands. She obtained her Ph.D. degree from Leiden University in 1985. In 1987, she received a 5-year personal fellowship from The Netherlands Organization for Scientific Research.
In 1992, she became staff scientist at the Netherlands Cancer Institute and was named the head of the Division of Immunology in 2002.[3] In 1999, she was appointed professor in Experimental Oncology at the University of Amsterdam.
Awards
She received the Van Loghem career award from the Dutch Society of Immunology in 2009.[4]
In 2012, she was elected EMBO member.
In 2018 she received the Delphine Parrott award for inspiring female scientists[5] by Megan MacLeod during the West of Scotland Immunology Group showcase at the University of Glasgow
Important work
- The structure of the human T cel receptor/CD3 complex.[6][7][8]
- The Gamma delta T cell[9] and the development of the first Antibody to detect these cells in humans.[10]
- The identification of TNF receptor CD27 and CD70 ligand as important costimulatory system on T cells [11][12][13]
References
- ↑ LUMC. "Prof. Jannie Borst benoemd tot hoogleraar Immunologie in Leiden | LUMC" (in nl-NL). https://www.lumc.nl/over-het-lumc/nieuws/2019/Februari/benoeming-jannie-borst/.
- ↑ LUMC. "Jannie Borst | LUMC" (in nl-NL). https://www.lumc.nl/org/ihb/overons/staf/Borst/.
- ↑ "Borst, Jannie". http://www.nki.nl/people/borst-jannie/.
- ↑ "Van Loghem Laureate Jannie Borst: A fascination for the complexity of life". https://www.dutchsocietyimmunology.nl/interviews/3258_interviewjanniebors.
- ↑ "West of Scotland Immunology Group Showcase 2018 | British Society for Immunology". https://www.immunology.org/civicrm/event/info?reset=1&id=529.
- ↑ Krangel, M. S.; Bierer, B. E.; Devlin, P.; Clabby, M.; Strominger, J. L.; McLean, J.; Brenner, M. B. (1987-06-01). "T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes.". Proceedings of the National Academy of Sciences 84 (11): 3817–3821. doi:10.1073/pnas.84.11.3817. ISSN 0027-8424. PMID 3108880. Bibcode: 1987PNAS...84.3817K.
- ↑ van den Elsen, Peter; Shepley, Beth-Ann; Borst, Jannie; Coligan, John E.; Markham, Alexander F.; Orkin, Stuart; Terhorst, Cox (November 1984). "Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex". Nature 312 (5993): 413–418. doi:10.1038/312413a0. ISSN 0028-0836. PMID 6095101. Bibcode: 1984Natur.312..413V.
- ↑ Jacobs, Heinz; Vandeputte, Dmitri; Tolkamp, Louis; De Vries, Evert; Borst, Jannie; Berns, Anton (April 1994). "CD3 components at the surface of pro-T cells can mediate pre-T cell developmentin vivo". European Journal of Immunology 24 (4): 934–939. doi:10.1002/eji.1830240423. ISSN 0014-2980. PMID 8149963.
- ↑ Haks, Mariëlle C.; Krimpenfort, Paul; Borst, Jannie; Kruisbeek, Ada M. (1998-04-01). "The CD3γ chain is essential for development of both the TCRαβ and TCRγδ lineages". The EMBO Journal 17 (7): 1871–1882. doi:10.1093/emboj/17.7.1871. ISSN 0261-4189. PMID 9524111.
- ↑ Spits, H.; Borst, J.; Tax, W.; Capel, P. J.; Terhorst, C.; de Vries, J. E. (September 1985). "Characteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen". Journal of Immunology 135 (3): 1922–1928. doi:10.4049/jimmunol.135.3.1922. ISSN 0022-1767. PMID 2410507.
- ↑ Borst, Jannie; Hendriks, Jenny; Xiao, Yanling (June 2005). "CD27 and CD70 in T cell and B cell activation". Current Opinion in Immunology 17 (3): 275–281. doi:10.1016/j.coi.2005.04.004. ISSN 0952-7915. PMID 15886117.
- ↑ Church, J. A. (2004-08-01). "Lethal T Cell Immunodeficiency Induced by Chronic Costimulation via CD27-CD70 Interactions". Pediatrics 114 (2): 552–553. doi:10.1542/peds.114.2.s1.552-b. ISSN 0031-4005.
- ↑ Arens, Ramon; Tesselaar, Kiki; Baars, Paul A; van Schijndel, Gijs M. W; Hendriks, Jenny; Pals, Steven T; Krimpenfort, Paul; Borst, Jannie et al. (2001-11-01). "Constitutive CD27/CD70 Interaction Induces Expansion of Effector-Type T Cells and Results in IFNγ-Mediated B Cell Depletion". Immunity 15 (5): 801–812. doi:10.1016/S1074-7613(01)00236-9. ISSN 1074-7613. PMID 11728341.
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