Biography:Jason Carroll (researcher)

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Short description: British medical researcher


Jason Carroll

FMedSci
Alma materUniversity of Melbourne
AwardsFellow of the Academy of Medical Sciences
Scientific career
InstitutionsCancer Research UK Cambridge Institute, University of Cambridge
Websitewww.cruk.cam.ac.uk/research-groups/carroll-group

Professor Jason Carroll FMedSci is a British medical researcher serving as a Senior Group Leader at the Cancer Research UK Cambridge Institute, University of Cambridge and Founder and Chief Scientific Officer of Azeria Therapeutics.[1][2] He is a Professor of Molecular Oncology assigned to the Department of Oncology[3] and a Fellow of Clare College, Cambridge.[4]

Education

Carroll completed his B.Sc Hons in Molecular Biology at the University of Melbourne before undertaking his PhD in Cancer Research at The Garvan Institute and University of New South Wales.[2]

Career

Carroll's research uses molecular, genomic and proteomic approaches to understand how the Estrogen Receptor causes gene transcription and how this contributes to breast cancer progression.[5] In 2008, Carroll discovered the molecular mechanism of tamoxifen in breast cancer, demonstrating that tamoxifen switched off the breast cancer gene ErbB2 via the protein Pax2, which acts as a switch. The team showed that tamoxifen resistance occurs when ErbB2 remains on.[6][7][8] Carroll also discovered the role of pioneer factor FOXA1 in breast cancer, demonstrating that it is key in enabling the estrogen receptor to interact with the DNA in breast cancer cells, switching on genes that trigger unchecked growth.[9][10] In 2015, Carroll's work uncovered why women who have high levels of both the estrogen and progesterone receptors have a better chance of breast cancer survival, and found that adding progesterone at the same time as tamoxifen slows tumour growth in the laboratory.[11][12][13]

In 2017, Carroll founded Azeria Therapeutics Limited to develop treatments for hormone resistant breast and prostate cancer, building on his work with pioneer factor FOXA1.[2][14][15]

Awards and honours

  • British Association for Cancer Research Frank Rose Young Scientist of the Year Award, 2009[16]
  • EMBO Young Investigator Award, 2010[17]
  • Cancer Research UK Future Leaders Award, 2012[18]
  • AACR Outstanding Investigator Award, 2013[19][20]
  • Louis-Jeantet Young Investigator Career Award, 2014[21]
  • EMBO member, 2016[22]
  • Academy of Medical Sciences Fellow, 2017[23][24]

References

  1. ↑ "Carroll Group". https://www.cruk.cam.ac.uk/research-groups/carroll-group. 
  2. ↑ 2.0 2.1 2.2 "Azeria Therapeutics | Developing pioneering cancer treatments". https://www.azeriatherapeutics.com/. 
  3. ↑ "Institute Group Leaders awarded promotions in the University". 2019-07-24. https://www.cruk.cam.ac.uk/2019/07/24/institute-group-leaders-awarded-promotions-in-the-university. 
  4. ↑ "Fellows of Clare College - Clare College Cambridge". http://www.clare.cam.ac.uk/Fellows-of-Clare-College/. 
  5. ↑ "Jason Carroll - Google Scholar Citations". https://scholar.google.com/citations?user=RsLo9p4AAAAJ&hl=en. 
  6. ↑ Carroll, Jason S.; Ali, Simak; Howat, William J.; Jiang, Jie; Myles Brown; Nicholson, Robert I.; Hutcheson, Iain R.; Geistlinger, Timothy R. et al. (December 2008). "Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to tamoxifen". Nature 456 (7222): 663–666. doi:10.1038/nature07483. ISSN 1476-4687. PMID 19005469. Bibcode: 2008Natur.456..663H. 
  7. ↑ "Breast drug failure cause found". 2008-11-13. http://news.bbc.co.uk/2/hi/health/7723185.stm. 
  8. ↑ "Scientists crack the code to tamoxifen resistance". 2008-11-13. https://www.cam.ac.uk/research/news/scientists-crack-the-code-to-tamoxifen-resistance. 
  9. ↑ Carroll, Jason S.; Schmidt, Dominic; Ross-Innes, Caryn S.; Holmes, Kelly A.; Hurtado, Antoni (January 2011). "FOXA1 is a key determinant of estrogen receptor function and endocrine response". Nature Genetics 43 (1): 27–33. doi:10.1038/ng.730. ISSN 1546-1718. PMID 21151129. 
  10. ↑ "Single gene essential for oestrogen response in breast cancer". 2013-12-05. https://www.cancerresearchuk.org/about-us/cancer-news/press-release/2010-12-12-single-gene-essential-for-oestrogen-response-in-breast-cancer. 
  11. ↑ editor, Ian Sample Science (2015-07-08). "Breast cancer hope as hormone shown to slow tumour growth". The Guardian. ISSN 0261-3077. https://www.theguardian.com/science/2015/jul/08/breast-cancer-hope-as-hormone-progesterone-shown-to-slow-tumour-growth. 
  12. ↑ "Solving a breast cancer mystery – why do 'double-positive' women do better?". 8 July 2015. https://scienceblog.cancerresearchuk.org/2015/07/08/solving-a-breast-cancer-mystery-why-do-double-positive-women-do-better/. 
  13. ↑ Carroll, Jason S.; Tilley, Wayne D.; Caldas, Carlos; Stingl, John; Perou, Charles M.; Launchbury, Rosalind; Silva, Grace; Robinson, Jessica L. L. et al. (July 2015). "Progesterone receptor modulates ERα action in breast cancer". Nature 523 (7560): 313–317. doi:10.1038/nature14583. ISSN 1476-4687. PMID 26153859. Bibcode: 2015Natur.523..313M. 
  14. ↑ "Azeria Therapeutics | Business Weekly | Technology News | Business news | Cambridge and the East of England". https://www.businessweekly.co.uk/killer-50/ones-watch/azeria-therapeutics. 
  15. ↑ Therapeutics, Azeria. "Azeria Therapeutics, the World's First Pioneer Factor Drug Discovery Company, Announces Series A Investment from Sixth Element Capital". https://www.prnewswire.co.uk/news-releases/azeria-therapeutics-the-worlds-first-pioneer-factor-drug-discovery-company-announces-series-a-692370281.html. 
  16. ↑ "BACR/AstraZeneca Young Scientist Frank Rose Award | BACR - The British Association for Cancer Research". https://www.bacr.org.uk/awards-/bacr-astrazeneca-young-scientist-frank-rose-award. 
  17. ↑ adit. "Twenty-one group leaders join network of EMBO Young Investigators". https://www.embo.org/news/press-releases/2010/twenty-one-group-leaders-join-network-of-embo-young-investigators. 
  18. ↑ "Future Leaders in Cancer Research Prize". 2015-10-28. https://www.cancerresearchuk.org/funding-for-researchers/how-we-deliver-research/our-research-prizes/future-leaders-in-cancer-research-prize. 
  19. ↑ "Jason Carroll receives AACR Outstanding Investigator Award Scholarship". 2013-09-26. https://www.cruk.cam.ac.uk/2013/09/26/congratulations-to-jason-carroll. 
  20. ↑ "AACR Outstanding Investigator Award for Breast Cancer Research, supported by The Breast Cancer Research Foundation". https://www.aacr.org:443/Research/Awards/Pages/outstanding-investigator-award___8470D6.aspx. 
  21. ↑ admin (2017-09-17). "Louis-Jeantet Young Investigator Career Award | Jeantet". https://www.jeantet.ch/en/archives/research/young-investigator/. 
  22. ↑ "Find people in the EMBO Communities". https://people.embo.org/profile/jason-s-carroll. 
  23. ↑ "The Academy of Medical Sciences announces new Fellows for 2017". 2017-05-08. https://www.cam.ac.uk/news/the-academy-of-medical-sciences-announces-new-fellows-for-2017. 
  24. ↑ "Dr Jason Carroll | The Academy of Medical Sciences". https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Dr-Jason-Carroll-0019117. 



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