Biology:FOXA1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene.[1][2][3]
Function
FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin as a pioneer factor. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.[1]
Marker in breast cancer
FOXA1 in breast cancer is highly correlated with ERα+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 acts as a pioneer factor for ERa in ERα+ breast cancer, and its expression might identify ERα+ cancers that undergo rapid reprogramming of ERa signaling that is associated with poor outcomes and treatment resistance.[4] Conversely, in ERα− breast cancer FOXA1 is highly correlated with low-grade morphology and improved disease free survival. FOXA1 is a downstream target of GATA3 in the mammary gland.[5] Expression in ERα− cancers may identify a subset of tumors that is responsive to other endocrine therapies such as androgen receptor antagonist treatment.[6][7]
Role in cancer
Mutations in this gene have been recurrently seen in instances of prostate cancer.[8]
Expression of FOXA1 correlates with two EMT markers, namely Twist1 and E-cadherin in breast cancer.[9]
References
- ↑ 1.0 1.1 "Entrez Gene: forkhead box A1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3169.
- ↑ "Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1307 (1): 17–20. June 1996. doi:10.1016/0167-4781(96)00058-9. PMID 8652662.
- ↑ "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics 39 (3): 417–419. February 1997. doi:10.1006/geno.1996.4477. PMID 9119385.
- ↑ "Differential oestrogen receptor binding is associated with clinical outcome in breast cancer". Nature 481 (7381): 389–393. January 2012. doi:10.1038/nature10730. PMID 22217937. Bibcode: 2012Natur.481..389R.
- ↑ "GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland". Cell 127 (5): 1041–1055. December 2006. doi:10.1016/j.cell.2006.09.048. PMID 17129787.
- ↑ "Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours". Breast Cancer Research 11 (3): R40. 2009. doi:10.1186/bcr2327. PMID 19549328.
- ↑ "Gene expression meta-analysis supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB family". BMC Medical Genomics 2: 59. September 2009. doi:10.1186/1755-8794-2-59. PMID 19747394.
- ↑ "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer". Nature Genetics 44 (6): 685–689. May 2012. doi:10.1038/ng.2279. PMID 22610119.
- ↑ "Association of FOXA1 and EMT markers (Twist1 and E-cadherin) in breast cancer". Molecular Biology Reports 46 (3): 3247–3255. June 2019. doi:10.1007/s11033-019-04784-w. PMID 30941644.
Further reading
- "Up-regulation of the HSP72 by Foxa1 in MCF-7 human breast cancer cell line". Biochemical and Biophysical Research Communications 386 (1): 30–34. August 2009. doi:10.1016/j.bbrc.2009.05.120. PMID 19486887.
- "ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer". Cancer Research 70 (1): 240–248. January 2010. doi:10.1158/0008-5472.CAN-09-2904. PMID 20048076.
- "A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland". Proceedings of the National Academy of Sciences of the United States of America 107 (1): 98–103. January 2010. doi:10.1073/pnas.0902001107. PMID 20018680. Bibcode: 2010PNAS..107...98M.
- "Upstream stimulatory factor 2, a novel FoxA1-interacting protein, is involved in prostate-specific gene expression". Molecular Endocrinology 23 (12): 2038–2047. December 2009. doi:10.1210/me.2009-0092. PMID 19846536.
- "[Diagnostic and prognostic significance of FOXA1 expression in molecular subtypes of breast invasive ductal carcinomas]". Zhonghua Yi Xue Za Zhi 90 (20): 1403–1407. May 2010. PMID 20646630.
- "Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort". BMC Cancer 9: 43. January 2009. doi:10.1186/1471-2407-9-43. PMID 19183483.
- "Stable chromatin binding prevents FoxA acetylation, preserving FoxA chromatin remodeling". The Journal of Biological Chemistry 285 (1): 464–472. January 2010. doi:10.1074/jbc.M109.063149. PMID 19897491.
- "Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM". Molecular and Cellular Biology 30 (2): 399–412. January 2010. doi:10.1128/MCB.00907-09. PMID 19917725.
- "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq". Genome Biology 10 (11): R129. 2009. doi:10.1186/gb-2009-10-11-r129. PMID 19919681.
- "Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers". Genome Research 19 (3): 372–380. March 2009. doi:10.1101/gr.084582.108. PMID 19129543.
- "FOXA1 as a therapeutic target for breast cancer". Expert Opinion on Therapeutic Targets 11 (4): 507–514. April 2007. doi:10.1517/14728222.11.4.507. PMID 17373880.
- "Role of FOXA in mitochondrial citrate carrier gene expression and insulin secretion". Biochemical and Biophysical Research Communications 385 (2): 220–224. July 2009. doi:10.1016/j.bbrc.2009.05.030. PMID 19445897.
- "FOXA1 is a potential oncogene in anaplastic thyroid carcinoma". Clinical Cancer Research 15 (11): 3680–3689. June 2009. doi:10.1158/1078-0432.CCR-08-3155. PMID 19470727.
- "FOXA1 in breast cancer". Expert Reviews in Molecular Medicine 11: e8. March 2009. doi:10.1017/S1462399409001008. PMID 19261198.
- "Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer". Cancer Research 70 (5): 2115–2125. March 2010. doi:10.1158/0008-5472.CAN-09-2979. PMID 20160041.
- "Overexpression of hepatocyte nuclear factor-3alpha induces apoptosis through the upregulation and accumulation of cytoplasmic p53 in prostate cancer cells". The Prostate 70 (4): 353–361. March 2010. doi:10.1002/pros.21069. PMID 19866472.
- "FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis". Development 137 (12): 2045–2054. June 2010. doi:10.1242/dev.043299. PMID 20501593.
- "Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours". Breast Cancer Research 11 (3): R40. 2009. doi:10.1186/bcr2327. PMID 19549328.
- "The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis". Bone 45 (2): 289–294. August 2009. doi:10.1016/j.bone.2009.03.676. PMID 19371798.
- "Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis". International Journal of Oncology 36 (2): 321–330. February 2010. doi:10.3892/ijo_00000503. PMID 20043065.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
