Biography:Kathy Niakan
Kathy Niakan | |
|---|---|
| Born | 1977 Memphis, Tennessee, USA [1] |
| Nationality | American [1] |
| Education | PhD in stem cell research |
| Alma mater | University of Washington, University of California, Los Angeles |
| Known for | One of the 100 most influential people in the world by Time (magazine) in April 2016.[2] |
| Scientific career | |
| Fields | Stem cell biology |
| Institutions | Francis Crick Institute |
Kathy Niakan is a developmental biologist, working in human developmental and stem cell biology. In 2016 she became the first scientist in the world to gain regulatory approval to edit the genomes of human embryos for research.[3]
Niakan was named as one of the 100 most influential people in the world by Time (magazine) in April 2016.[2]
Biography
Kathy Niakan obtained a BSc in cell and molecular biology and a BA in English literature from the University of Washington. In 2005, Niakan obtained her PhD in stem cell and developmental biology from the University of California, Los Angeles, where she worked in the laboratory of Edward McCabe.[4] She went on to be a research fellow with Kevin Eggan at Harvard University, working with human and mouse stem cells to study human embryogenesis and cell potency. She then moved to the University of Cambridge Anne McLaren Laboratory for Stem Cell Biology in the Cambridge Biomedical Campus where she continued to investigate the molecular basis of early cell development in humans and mice.[5] In 2013, Niakan became a group leader at the MRC National Institute for Medical Research (NIMR) in London. Since 2015, she has been a group leader at the Francis Crick Institute,[4] the successor institute to the NIMR.[6]
She was a finalist in the inaugorary UK Blavatnik Awards for Young Scientists in 2019.[7]
In 2021, Professor Kathy Niakan was appointed as an honorary group leader in the Epigenetics research programme as part of the Babraham Institute. The Babraham Institute pioneers world-changing scientific developments, and focuses on cellular signalling, gene regulation, immunology, and the impact of epigenetic regulation at different stages of life. This new appointment and leadership position will hopefully allow Kathy to collaborate with others in her field and continue vital research.[8]
Research
At the Francis Crick Institute she is investigating the mechanisms of lineage specification in human embryos and stem cells.[5]
In February 2016 Niakan was given the go-ahead by the UK Human Fertilisation and Embryology Authority to genetically modify human embryos. The embryos were to be destroyed after seven days.[9] She planned to use the CRISPR technique to answer questions like what genetic faults cause some women to miscarry, what causes infertility and what is crucial for a healthy embryo.[5][10] In 2017 her lab published the first major study using CRISPR-Cas9 in human embryos in Nature, demonstrating that the transcription factor Oct4 is essential for fetal development.[11]
In addition to her pioneering research, Professor Niakan has engaged with policy makers, funders and the public to provide expert advice on genome editing.
References
- ↑ 1.0 1.1 "Dr Kathy Niakan honoured by TIME magazine". https://www.crick.ac.uk/news/2016-04-21-niakan-time-100.
- ↑ 2.0 2.1 Doudna, Jennfer (2016-04-21). "Kathy Niakan". Time Magazine. http://time.com/4301356/kathy-niakan-2016-time-100/.
- ↑ Callaway, Ewen (2016). "UK scientists gain licence to edit genes in human embryos". Nature 530 (7588): 18. doi:10.1038/nature.2016.19270. PMID 26842037. Bibcode: 2016Natur.530...18C.
- ↑ 4.0 4.1 "Kathy Niakan" (in en). https://www.crick.ac.uk/research/find-a-researcher/kathy-niakan.
- ↑ 5.0 5.1 5.2 "Kathy Niakan: Biography". https://www.crick.ac.uk/research/a-z-researchers/researchers-k-o/kathy-niakan/biography/. Retrieved 15 February 2016.
- ↑ "Our founders" (in en). https://www.crick.ac.uk/about-us/our-history/our-founders.
- ↑ "Kathy Niakan | Blavatnik Awards for Young Scientists". http://blavatnikawards.org/honorees/profile/kathy-niakan/.
- ↑ "Epigenetics programme welcomes Professor Kathy Niakan as honorary group leader | Babraham Institute". https://www.babraham.ac.uk/news/2021/09/epigenetics-programme-welcomes-professor-kathy-niakan-honorary-group-leader.
- ↑ Gallagher, James (February 2016). "Scientists get 'gene editing' go-ahead". BBC News. https://www.bbc.co.uk/news/health-35459054. Retrieved 15 February 2016.
- ↑ Walsh, Fergus (2016-06-06). "Gene editing technique could transform future". https://www.bbc.co.uk/news/health-36439260.
- ↑ Fogarty, Norah M. E.; McCarthy, Afshan; Snijders, Kirsten E.; Powell, Benjamin E.; Kubikova, Nada; Blakeley, Paul; Lea, Rebecca; Elder, Kay et al. (2017-09-20). "Genome editing reveals a role for OCT4 in human embryogenesis" (in En). Nature 550 (7674): 67–73. doi:10.1038/nature24033. ISSN 0028-0836. PMID 28953884. Bibcode: 2017Natur.550...67F.
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