Biography:Theresa M. Reineke

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Short description: American chemist

Theresa M. Reineke (born January 1, 1972) is an American chemist and Distinguished McKnight University Professor at the University of Minnesota. She designs sustainable, environmentally friendly polymer-based delivery systems for targeted therapeutics. She is the associate editor of ACS Macro Letters.

Early life and education

Reineke earned her bachelor's degree at University of Wisconsin–Eau Claire.[1] She moved to Arizona State University for her graduate studies and earned a master's degree in 1998.[1][2] Reineke was a PhD student at the University of Michigan, where she was supervised by Michael O'Keeffe and Omar M. Yaghi.[1][3] She was awarded the Wirt and Mary Cornell Prize for Outstanding Graduate Research. Reineke joined the California Institute of Technology as an National Institutes of Health postdoctoral fellow in 2000.[1]

Research and career

Reineke joined the University of Minnesota in 2011. Her research group focus on the design, characterisation and functionalisation of macromolecular systems.[4][5] These macromolecules include biocompatible polymers that can deliver DNA for regenerative medicine as well as targeted therapeutic treatments.[4] She was made a Lloyd H. Reyerson Professor with tenure at the University of Minnesota in 2011.[1] Reineke has published over 140 papers.[6]

Nucleic acids can have an unparalleled specificity for targets inside a cell, but need to be compacted into nanostructures (polyplexes) that can enter cells.[7] Reineke designs polymer-based transportation systems for nucleic acids.[7] These polymer vehicles can improve the solubility and bioavailability of drugs.[8] These often incorporate carbohydrates, which have an affinity for polyplexes and are non-toxic.[7] She is a member of the University of Minnesota Centre for Sustainable Polymers, synthesising polymers from sustainable ingredients. The carbohydrate units within her polymer drug delivery systems are a widely available, renewable resource.[9] The sustainable polymers designed by Reineke include poly(ester-thioethers).[9]

Reineke used reversible addition−fragmentation chain-transfer polymerization for the synthesis of diblock terpolymers that can be used for targeted drug delivery.[10] She used spray dried dispersions of the polymer with the drug probucol.[11]

Reineke was made a University of Minnesota Distinguished McKnight University Professor in 2017.[1] She is the associate editor of ACS Macro Letters and on the Advisory Board of Biomacromolecules, Bioconjugate Chemistry and Polymer Chemistry.[1] She is a member of the American Chemical Society Polymer Division.[12] Her work has been supported by an National Science Foundation CAREER Award, a Sloan Research Fellowship, the National Institutes of Health and the National Academy of Sciences.[13]

Awards and honors

Patents

  • 2014 Monomers, polymers and articles containing the same from sugar derived compounds[25]
  • 2018 Isosorbide-based polymethacrylates[26]

External links

References

  1. Jump up to: 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 "Dr. Theresa M. Reineke" (in en-US). http://reinekegroup.org/group/dr-theresa-m-reineke. 
  2. "Nonviral Synthetic Polymers Promote Cellular and In Vivo Delivery of Therapeutic Genes and Editing Systems". https://breakthroughsymposium.com/schedule/theresa-m-reineke/. 
  3. "Chemistry Tree – Theresa M. Reineke". https://academictree.org/chemistry/peopleinfo.php?pid=67659. 
  4. Jump up to: 4.0 4.1 "Research" (in en-US). http://reinekegroup.org/research. 
  5. Aldevron (2018-12-04), Theresa Reineke; Breakthrough Symposium Presenter, https://vimeo.com/304455913, retrieved 2019-04-17 
  6. "Publications Archive - Page 2 of 2 - The Reineke Group" (in en-US). https://reinekegroup.org/publications/page/2. 
  7. Jump up to: 7.0 7.1 7.2 "Nucleic Acid Delivery" (in en-US). http://reinekegroup.org/nucleic-acid-delivery. 
  8. Stanford, © Stanford University; Notice, California 94305 Copyright Complaints Trademark. "2019 Winter Talk (Theresa M. Reineke, University of Minnesota) | Stanford Polymer Collective" (in en). https://web.stanford.edu/group/polymercollective/cgi-bin/wordpress/?p=3611. 
  9. Jump up to: 9.0 9.1 "Sustainable Polymers" (in en-US). http://reinekegroup.org/sustainable-polymers. 
  10. "Oral Drug Delivery" (in en-US). http://reinekegroup.org/oral-drug-delivery. 
  11. Tale, Swapnil; Purchel, Anatolii A.; Dalsin, Molly C.; Reineke, Theresa M. (2017-09-22). "Diblock Terpolymers Are Tunable and pH Responsive Vehicles To Increase Hydrophobic Drug Solubility for Oral Administration". Molecular Pharmaceutics 14 (11): 4121–4127. doi:10.1021/acs.molpharmaceut.7b00458. ISSN 1543-8384. PMID 28937226. 
  12. "Reineke – address". http://old.polyacs.org/211.html. 
  13. "Fellows Database | Alfred P. Sloan Foundation" (in en). https://sloan.org/fellows-database. 
  14. "Faculty Awards". https://www.artsci.uc.edu/departments/chemistry/faculty-and-staff/faculty-awards.html. 
  15. "Outstanding New Investigator Awards | ASGCT – American Society of Gene & Cell Therapy | ASGCT – American Society of Gene & Cell Therapy". https://www.asgct.org/research/grants-awards/outstanding-new-investigator-awards. 
  16. "MP's Reineke receives Macro 2012 Lecture Award | IPRIME". http://iprime.umn.edu/mps-reineke-receives-macro-2012-lecture-award. 
  17. "Theresa M. Reineke, Ph.D. COF-2038 – AIMBE" (in en). https://aimbe.org/college-of-fellows/cof-2038/. 
  18. "Reineke selected 2016 Sara Evans Faculty Woman Scholar | Center for Sustainable Polymers" (in en-US). https://csp.umn.edu/2016/08/02/reineke-selected-2016-sara-evans-faculty-woman-scholar/. 
  19. "Theresa Reinke, of IPrime's polymer group, receives Talyor Award for Distinguished Research | IPRIME". http://www.iprime.umn.edu/theresa-reinke-iprime%E2%80%99s-polymer-group-receives-talyor-award-distinguished-research. 
  20. "Carl S. Marvel Award for Creative Polymer Chemistry" (in en-US). 2017-11-28. https://polyacs.org/carl-s-marvel-award-for-creative-polymer-chemistry/. 
  21. "DuPont Nutrition & Health Honors 2018 Science Excellence and Microbiome Science Award Medalists – DuPont | Danisco". https://www.dupontnutritionandhealth.com/news/nutrition-health/2018/dupont-nutrition-health-honors-2018-science-excellence-and-microbiome-science-award-medalists.html. 
  22. harva015 (2018-10-11). "Reineke honored with DuPont Nutrition & Health Science Excellence Medal" (in en). https://chem.umn.edu/news/reineke-honored-dupont-nutrition-health-science-excellence-medal. 
  23. harva015 (2018-02-22). "Professor Reineke named a 2018 POLY Fellow" (in en). https://chem.umn.edu/news/professor-reineke-named-2018-poly-fellow. 
  24. "News | MRSEC". http://mrsec.umn.edu/news-highlights/news/. 
  25. "US Patent for Monomers, polymers and articles containing the same from sugar derived compounds Patent (Patent # 9,505,778 issued November 29, 2016) – Justia Patents Search". https://patents.justia.com/patent/9505778. 
  26. "US Patent for Isosorbide-based polymethacrylates Patent (Patent # 9,988,393 issued June 5, 2018) – Justia Patents Search" (in en). https://patents.justia.com/patent/9988393.