Biography:Wojciech Karlowski

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Short description: Polish biologist specializing in molecular biology and bioinformatics
Wojciech Karlowski
Wojciech Karłowski
WMK 3.jpg
BornJanuary 10, 1966
Poland
NationalityPolish
Alma materAdam Mickiewicz University
Known forhigh-throughput analyses and functional annotation of biological sequences, identification of non-coding RNAs
Scientific career
Fieldsbioinformatics, computational biology, molecular biology, molecular genetics, genomics
InstitutionsAdam Mickiewicz University in Poland, University of California Los Angeles / USA, Institute of Bioinformatics (MIPS) in Munich / Germany
ThesisGenes encoding nodule-specific proline-rich proteins from yellow lupine (1996)
Doctoral advisorAndrzej B. Legocki
Websitehttp://combio.pl/

Wojciech Maciej Karlowski (Polish pronunciation: [vɔj.t͡ɕɛx karlɔvski]; born January 10, 1966) is a Polish biologist specializing in molecular biology and bioinformatics, [1] and a full professor in biological sciences.[2] He is Head of the Department of Computational Biology at the Faculty of Biology at the Adam Mickiewicz University in Poznan. His major scientific interests include identification of non-coding RNAs, genomics, high-throughput analyses, and functional annotation of biological sequences.

Scientific biography

Karlowski graduated in molecular biology from the Faculty of Biology at the Adam Mickiewicz University in Poznan in 1991.[1]

From 1991 to 1996 Karlowski continued his education in the area of plant molecular genetics in the frame of the Adam Mickiewicz University Ph.D. School. His research concentrated on molecular mechanisms of symbiotic nitrogen fixation of leguminous plants. He defended his Ph.D. dissertation “Genes encoding nodule-specific proline-rich proteins from yellow lupine” in 1996 under the supervision of Andrzej B. Legocki.[1]

Karłowski completed his postdoctoral fellowship in the laboratory of Ann Hirsch in the Institute of Molecular, Cell and Developmental Biology at the University of California in Los Angeles (UCLA).[3] He was conducting experiments related to molecular aspects of symbiotic interactions between leguminous plants and bacteria, including characterization of a novel gene identified in alfalfa (Medicago sativa) mutant blocked at the early stages of symbiotic nodules development.[4]

In the early 2000s, Karlowski worked as a Scientist in the group of Klaus F. X. Mayer in the Institute of Bioinformatics/Munich Information Center for Protein Sequences (MIPS) in Munich.[5][6][7] He was involved in research on computational genomics of plants in a collaboration with Arizona Genomics Institute, Whitehead Institute MIT, and Rutgers University. One of his scientific achievements during that time was related to a bioinformatic analysis of data generated during the early stages of corn (Zea mays) genome sequencing. A novel approach and application of advanced computational biology techniques to the project allowed the first view at the composition and evolutionary history of the corn genome.[8]

Karlowski then took a position at the Faculty of Biology at the Adam Mickiewicz University in Poznan and also completed an internship at the University in Perpignan in France . At this time, he started a scientific project dedicated to a bioinformatic analysis of protein domains involved in silencing of transcription in a collaboration with Thierry Lagrange.[9][10] In 2008 Wojciech Karlowski was appointed as a visiting professor at the University of Perpignan and collaborated with Manuel Echeverria on the functional characterization of miRNA in rice.[11] In the same year, the Faculty of Biology Council awarded him with the habilitation degree (D. Sc) in biology.[1] Karlowski was nominated as an associate professor in the Laboratory of Bioinformatics at the Adam Mickiewicz University and he established his research group that worked on projects related to genomics, biological data analysis, and non-coding RNAs.[12]

In 2014 Karlowski received a nomination of a professor in biological sciences from the President of the Republic of Poland.[2] In the same year, he took the position of professor at the Faculty of Biology at the Adam Mickiewicz University in Poznan and established the Department of Computational Biology.[citation needed] His research group works on scientific projects related to the exploration of biological data. They investigate the properties of biological processes using computational tools and employ high-throughput methods for comparative, functional, and evolutionary molecular biology analyses.[13][14][15][16][17]

Major scientific achievements

Karlowski is an expert in bioinformatics, molecular biology, molecular genetics, and genomics. He is an author and co-author of numerous publications in international journals.[18][19] Among some of his achievements are:

References

  1. ↑ 1.0 1.1 1.2 1.3 "Polish Science Person Profile". https://nauka-polska.pl/#/profile/scientist?id=95541&lang=en&_k=y5w6xy. 
  2. ↑ 2.0 2.1 Kluwer, Wolters. "Nadanie tytułu profesora." (in pl). https://sip.lex.pl/akty-prawne/mp-monitor-polski/nadanie-tytulu-profesora-18135111. 
  3. ↑ "People – Lab of Ann Hirsch". https://sites.lifesci.ucla.edu/mcdb-hirschlab/people-2/. 
  4. ↑ Karlowski, Wojciech M. (2003). "The over-expression of an alfalfa RING-H2 gene induces pleiotropic effects on plant growth and development". Plant Molecular Biology 52 (1): 121–133. doi:10.1023/A:1023916701669. PMID 12825694. http://link.springer.com/10.1023/A:1023916701669. 
  5. ↑ Shiu, Shin-Han; Karlowski, Wojciech M.; Pan, Runsun; Tzeng, Yun-Huei; Mayer, Klaus F. X.; Li, Wen-Hsiung (2004). "Comparative Analysis of the Receptor-Like Kinase Family in Arabidopsis and Rice" (in en). The Plant Cell 16 (5): 1220–1234. doi:10.1105/tpc.020834. ISSN 1040-4651. PMID 15105442. 
  6. ↑ Karlowski, W. M. (2003-01-01). "MOsDB: an integrated information resource for rice genomics". Nucleic Acids Research 31 (1): 190–192. doi:10.1093/nar/gkg073. PMID 12519979. 
  7. ↑ Schrick, Kathrin; Nguyen, Diana; Karlowski, Wojciech M; Mayer, Klaus FX (2004). "START lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors". Genome Biology 5 (6): R41. doi:10.1186/gb-2004-5-6-r41. PMID 15186492. 
  8. ↑ Messing, J.; Bharti, A. K.; Karlowski, W. M.; Gundlach, H.; Kim, H. R.; Yu, Y.; Wei, F.; Fuks, G. et al. (2004-10-05). "Sequence composition and genome organization of maize" (in en). Proceedings of the National Academy of Sciences 101 (40): 14349–14354. doi:10.1073/pnas.0406163101. ISSN 0027-8424. PMID 15388850. Bibcode: 2004PNAS..10114349M. 
  9. ↑ Karlowski, Wojciech M.; Zielezinski, Andrzej; Carrère, Julie; Pontier, Dominique; Lagrange, Thierry; Cooke, Richard (2010). "Genome-wide computational identification of WG/GW Argonaute-binding proteins in Arabidopsis" (in en). Nucleic Acids Research 38 (13): 4231–4245. doi:10.1093/nar/gkq162. ISSN 1362-4962. PMID 20338883. 
  10. ↑ Pontier, Dominique; Picart, Claire; Roudier, François; Garcia, Damien; Lahmy, Sylvie; Azevedo, Jacinthe; Alart, Emilie; Laudié, Michèle et al. (2012). "NERD, a Plant-Specific GW Protein, Defines an Additional RNAi-Dependent Chromatin-Based Pathway in Arabidopsis" (in en). Molecular Cell 48 (1): 121–132. doi:10.1016/j.molcel.2012.07.027. PMID 22940247. 
  11. ↑ Lin, S.-I.; Santi, C.; Jobet, E.; Lacut, E.; El Kholti, N.; Karlowski, W. M.; Verdeil, J.-L.; Breitler, J. C. et al. (2010-12-01). "Complex Regulation of Two Target Genes Encoding SPX-MFS Proteins by Rice miR827 in Response to Phosphate Starvation" (in en). Plant and Cell Physiology 51 (12): 2119–2131. doi:10.1093/pcp/pcq170. ISSN 0032-0781. PMID 21062869. 
  12. ↑ "Department of Computational Biology". http://ibmib.home.amu.edu.pl/en/department-of-computational-biology/. 
  13. ↑ "Research at Computational Biology Department AMU". http://combio.pl/research.php. 
  14. ↑ Zielezinski, Andrzej; Girgis, Hani Z.; Bernard, Guillaume; Leimeister, Chris-Andre; Tang, Kujin; Dencker, Thomas; Lau, Anna Katharina; Röhling, Sophie et al. (2019). "Benchmarking of alignment-free sequence comparison methods" (in en). Genome Biology 20 (1): 144. doi:10.1186/s13059-019-1755-7. ISSN 1474-760X. PMID 31345254. 
  15. ↑ Zielezinski, Andrzej; Karlowski, Wojciech M. (2015-02-01). "Integrative data analysis indicates an intrinsic disordered domain character of Argonaute-binding motifs" (in en). Bioinformatics 31 (3): 332–339. doi:10.1093/bioinformatics/btu666. ISSN 1460-2059. PMID 25304778. 
  16. ↑ The RNAcentral Consortium; Sweeney, Blake A; Petrov, Anton I; Burkov, Boris; Finn, Robert D; Bateman, Alex; Szymanski, Maciej; Karlowski, Wojciech M et al. (2019-01-08). "RNAcentral: a hub of information for non-coding RNA sequences" (in en). Nucleic Acids Research 47 (D1): D221–D229. doi:10.1093/nar/gky1034. ISSN 0305-1048. PMID 30395267. 
  17. ↑ Thompson, Agnieszka; Zielezinski, Andrzej; Plewka, Patrycja; Szymanski, Maciej; Nuc, Przemyslaw; Szweykowska-Kulinska, Zofia; Jarmolowski, Artur; Karlowski, Wojciech M (2018-01-01). "tRex: A Web Portal for Exploration of tRNA-Derived Fragments in Arabidopsis thaliana" (in en). Plant and Cell Physiology 59 (1): e1. doi:10.1093/pcp/pcx173. ISSN 0032-0781. PMID 29145635. https://academic.oup.com/pcp/article/59/1/e1/4627829. 
  18. ↑ "Google Scholar Profile for Wojciech Karlowski". https://scholar.google.com/citations?hl=en&user=XX1GbB8AAAAJ. 
  19. ↑ "ORCID Profile for Wojciech Karlowski". https://orcid.org/0000-0002-8086-5404. 

External links



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