Biography:Xiaojiang Chen

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Short description: Chinese-American virologist, immunologist, and structural biologist
Xiaojiang S. Chen
Born1963 (age 60–61)
Hunan, China
Known forVirology, Immunology, Molecular Biology and Structural Biology
Academic background
EducationBS in Biology
PhD in Biochemistry and Molecular Biology, Virology
Alma materShihezi University, China
University of California, USA
Academic work
InstitutionsUniversity of Southern California (USC), USA
University of Colorado, USA
Harvard University, USA

Xiaojiang S. Chen (Chinese: 陈小江; born in 1963) is a Chinese-American virologist, immunologist, and structural biologist. He is a professor of Biological Sciences and Chemistry and Director of the Center of Excellence in Nano Biophysics/Structural Biology at the University of Southern California.[1]

Chen is most known for his work on structural molecular virology and cancer biology.[2] He has made distinct discoveries in the fields of viral replication,[3] tumor suppression,[4][5] cell proliferation,[6] and DNA transaction (replication, mutation and repair).[7][8][9]

Chen is a Fellow of the American Association for the Advancement of Science (AAAS).[10]

Early life and education

Chen was born in Hunan, China in 1963. He completed his bachelor's degree from Shihezi University based in China in 1982 and moved to California where he earned his PhD in Biochemistry and Molecular Biology, Virology from the University of California, Davis under the guidance of George Bruening.[11][12] Following his Ph.D., he undertook a post-doctoral fellowship with Stephen C. Harrison at Harvard University studying X-ray crystallography and structural molecular virology.[13][14]

Career

In 1999, Chen became an assistant professor at the University of Colorado, School of Medicine, and was promoted to associate professor in 2003. Following that, he joined the University of Southern California (USC) in 2004 as a professor of Biological Sciences and Chemistry in USC Dornsife College and as an adjunct professor at Norris Cancer Center in the Keck School of Medicine at USC. He is currently appointed as Founding Director at the Center of Excellence NanoBiophysics/Structural Biology at USC.[15] Since 2016, he has been serving as a member of the Scientific Advisory board at Tower Cancer Research Foundation.[16]

Awards and honors

  • 2017 – Elected Fellow of the American Association for the Advancement of Science (AAAS)[10]

References

  1. ↑ "Faculty Profile > USC Dana and David Dornsife College of Letters, Arts and Sciences". http://dornsife.usc.edu/wrapper/cf/faculty-and-staff/faculty.cfm. 
  2. ↑ "Xiaojiang S. Chen | University of Southern California | 111 Publications | 6639 Citations | Related Authors". https://typeset.io/authors/xiaojiang-s-chen-4kr4r242u6. 
  3. ↑ Ito, Fumiaki; Alvarez-Cabrera, Ana L.; Liu, Shiheng; Yang, Hanjing; Shiriaeva, Anna; Zhou, Z. Hong; Chen, Xiaojiang S. (January 4, 2023). "Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase". Science Advances 9 (1): eade3168. doi:10.1126/sciadv.ade3168. PMID 36598981. Bibcode: 2023SciA....9E3168I. 
  4. ↑ Lilyestrom, Wayne; Klein, Michael G.; Zhang, Rongguang; Joachimiak, Andrzej; Chen, Xiaojiang S. (September 1, 2006). "Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor". Genes & Development 20 (17): 2373–2382. doi:10.1101/gad.1456306. PMID 16951253. 
  5. ↑ Li, Dawei; Zhao, Rui; Lilyestrom, Wayne; Gai, Dahai; Zhang, Rongguang; DeCaprio, James A.; Fanning, Ellen; Jochimiak, Andrzej et al. (May 10, 2003). "Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen". Nature 423 (6939): 512–518. doi:10.1038/nature01691. PMID 12774115. Bibcode: 2003Natur.423..512L. 
  6. ↑ Yang, Hanjing; Kim, Kyumin; Li, Shuxing; Pacheco, Josue; Chen, Xiaojiang S. (December 5, 2022). "Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G". Nature Communications 13 (1): 7498. doi:10.1038/s41467-022-35201-9. PMID 36470880. Bibcode: 2022NatCo..13.7498Y. 
  7. ↑ Fu, Yang; Ito, Fumiaki; Zhang, Gewen; Fernandez, Braulio; Yang, Hanjing; Chen, Xiaojiang S. (October 1, 2015). "DNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B". The Biochemical Journal 471 (1): 25–35. doi:10.1042/BJ20150382. PMID 26195824. 
  8. ↑ Gai, Dahai; Zhao, Rui; Li, Dawei; Finkielstein, Carla V.; Chen, Xiaojiang S. (October 1, 2004). "Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen". Cell 119 (1): 47–60. doi:10.1016/j.cell.2004.09.017. PMID 15454080. 
  9. ↑ G, Chandramouly; J, Zhao; S, McDevitt; T, Rusanov; T, Hoang; N, Borisonnik; T, Treddinick; Fw, Lopezcolorado et al. (June 11, 2021). "Polθ reverse transcribes RNA and promotes RNA-templated DNA repair". Science Advances 7 (24). doi:10.1126/sciadv.abf1771. PMID 34117057. Bibcode: 2021SciA....7.1771C. 
  10. ↑ 10.0 10.1 "2017 AAAS Fellows Recognized for Advancing Science | American Association for the Advancement of Science (AAAS)". https://www.aaas.org/news/2017-aaas-fellows-recognized-advancing-science. 
  11. ↑ Chen, X.; Bruening, G. (April 10, 1992). "Nucleotide sequence and genetic map of cowpea severe mosaic virus RNA 2 and comparisons with RNA 2 of other comoviruses". Virology 187 (2): 682–692. doi:10.1016/0042-6822(92)90471-z. PMID 1546463. https://pubmed.ncbi.nlm.nih.gov/1546463/. 
  12. ↑ Chen, Xiaojiang; Bruening, George (December 1, 1992). "Cloned DNA copies of cowpea severe mosaic virus genomic RNAs: Infectious transcripts and complete nucleotide sequence of RNA 1". Virology 191 (2): 607–618. doi:10.1016/0042-6822(92)90236-I. PMID 1448917. https://dx.doi.org/10.1016/0042-6822%2892%2990236-I. 
  13. ↑ Xs, Chen; Rl, Garcea; I, Goldberg; G, Casini; Sc, Harrison (March 10, 2000). "Structure of small virus-like particles assembled from the L1 protein of human papillomavirus 16". Molecular Cell 5 (3): 557–567. doi:10.1016/s1097-2765(00)80449-9. PMID 10882140. 
  14. ↑ Chen, X. S. (June 15, 1998). "Interaction of polyomavirus internal protein VP2 with the major capsid protein VP1 and implications for participation of VP2 in viral entry". The EMBO Journal 17 (12): 3233–3240. doi:10.1093/emboj/17.12.3233. PMID 9628860. PMC 1170661. http://emboj.embopress.org/cgi/doi/10.1093/emboj/17.12.3233. 
  15. ↑ "About Us > NanoBiophysics > USC Dana and David Dornsife College of Letters, Arts and Sciences". http://dornsife.usc.edu/nanobiophysicscore/. 
  16. ↑ "Scientific Advisory Board". https://www.towercancer.org/our-research/#advisory-board. 



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