Biology:2-oxoaldehyde dehydrogenase (NAD+)
From HandWiki
Short description: Enzyme
| 2-oxoaldehyde dehydrogenase (NAD) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.2.1.23 | ||||||||
| CAS number | 37250-91-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2-oxoaldehyde dehydrogenase (NAD+) (EC 1.2.1.23) is an enzyme that catalyzes the chemical reaction
- a 2-oxoaldehyde + NAD+ + H2O [math]\displaystyle{ \rightleftharpoons }[/math] a 2-oxo acid + NADH + H+
The 3 substrates of this enzyme are 2-oxoaldehyde, NAD+, and H2O, whereas its 3 products are 2-oxo acid, NADH, and H+.
This enzyme participates in pyruvate metabolism.
Nomenclature
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NAD+ 2-oxidoreductase. Other names in common use include:
- alpha-ketoaldehyde dehydrogenase
- methylglyoxal dehydrogenase
- NAD+-linked alpha-ketoaldehyde dehydrogenase
- 2-ketoaldehyde dehydrogenase
- NAD+-dependent alpha-ketoaldehyde dehydrogenase
- 2-oxoaldehyde dehydrogenase (NAD+)
See also
References
- Monder C (1967). "Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate". J. Biol. Chem. 242 (20): 4603–9. PMID 4383524.
- "On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase". J. Biol. Chem. 257 (18): 10571–4. 1982. PMID 7107626.
- "Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate". J. Biol. Chem. 257 (18): 10566–70. 1982. PMID 7107625.
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