Biology:4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
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Short description: Class of enzymes
| 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.7.1.17 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase (EC 3.7.1.17, tesD (gene), hsaD (gene)) is an enzyme with systematic name 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase ( (2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction
- (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate
The enzyme is involved in the bacterial degradation of the steroid ring structure.
References
- ↑ "Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441". Applied and Environmental Microbiology 71 (9): 5275–81. September 2005. doi:10.1128/aem.71.9.5275-5281.2005. PMID 16151114. Bibcode: 2005ApEnM..71.5275H.
- ↑ "A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages". Proceedings of the National Academy of Sciences of the United States of America 104 (6): 1947–52. February 2007. doi:10.1073/pnas.0605728104. PMID 17264217. Bibcode: 2007PNAS..104.1947V.
- ↑ "Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis". Acta Crystallographica Section F 64 (Pt 1): 2–7. January 2008. doi:10.1107/s1744309107065931. PMID 18097091.
- ↑ "Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism". The Journal of Biological Chemistry 285 (1): 434–43. January 2010. doi:10.1074/jbc.m109.058081. PMID 19875455.
External links
- 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate+hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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