Biology:ABCF2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
ATP-binding cassette sub-family F member 2 is a protein that in humans is encoded by the ABCF2 gene.[1][2]
Function
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This protein is a member of the GCN20 subfamily. Alternative splicing of this gene results in multiple transcript variants.[2]
ABCF2 acts as a suppressor of the volume-sensitive outwardly rectifying Cl channel (CLCN3).[3]
See also
References
- ↑ "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics 5 (10): 1649–55. October 1996. doi:10.1093/hmg/5.10.1649. PMID 8894702.
- ↑ 2.0 2.1 "Entrez Gene: ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10061.
- ↑ "Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells". Journal of Cellular Physiology 227 (10): 3498–510. 2012. doi:10.1002/jcp.24050. PMID 22252987.
Further reading
- "An inventory of the human ABC proteins". Biochimica et Biophysica Acta (BBA) - Biomembranes 1461 (2): 237–62. December 1999. doi:10.1016/s0005-2736(99)00161-3. PMID 10581359.
- "The human ATP-binding cassette (ABC) transporter superfamily". Genome Research 11 (7): 1156–66. July 2001. doi:10.1101/gr.184901. PMID 11435397.
- "Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein". Journal of Molecular Biology 285 (1): 379–89. January 1999. doi:10.1006/jmbi.1998.2259. PMID 9878413.
- "M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein". FEBS Letters 478 (1–2): 89–94. July 2000. doi:10.1016/S0014-5793(00)01823-8. PMID 10922475.
- "cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs". Biochemical and Biophysical Research Communications 275 (1): 223–7. August 2000. doi:10.1006/bbrc.2000.3282. PMID 10944468.
- "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast 18 (1): 69–80. January 2001. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.
- "Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses". Clinical Cancer Research 11 (19 Pt 1): 6880–8. October 2005. doi:10.1158/1078-0432.CCR-05-0751. PMID 16203778.
- "Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs". Human Pathology 38 (1): 134–9. January 2007. doi:10.1016/j.humpath.2006.06.026. PMID 16996567.
External links
- ABCF2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- ABCF2 human gene location in the UCSC Genome Browser.
- ABCF2 human gene details in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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