Biology:CLCN3

Short description: Protein-coding gene in humans

Generic protein structure example

2Cl^-/H⁺ exchanger 3 is a protein that in humans is encoded by the CLCN3 gene.

Interactions

CLCN3 has been shown to interact with PDZK1 and TMEM9.

See also

• Chloride channel

Further reading

• "Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity". Nature Communications 16: 1-17. 2025. doi:10.1038/s41467-025-58546-3. PMID 40169677. 

• "Structural basis of ClC-3 transporter inhibition by TMEM9 and PtdIns(3,5)P2". Nat Struct Mol Biol 32 (10): 1972-1979. 2025. doi:10.1038/s41594-025-01617-2. PMID 40670814. 
• "Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein". Genomics 27 (1): 131–41. 1995. doi:10.1006/geno.1995.1015. PMID 7665160. 
• "Refined localisation of the voltage-gated chloride channel, CLCN3, to 4q33". Hum. Genet. 102 (2): 178–81. 1998. doi:10.1007/s004390050673. PMID 9521585. 
• "Ion transporters and receptors in cDNA libraries from lens and cornea epithelia". Curr. Eye Res. 17 (7): 708–19. 1998. doi:10.1080/02713689808951247. PMID 9678416. 
• "Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome". EMBO J. 17 (23): 6879–87. 1998. doi:10.1093/emboj/17.23.6879. PMID 9843494. 
• "Expression of CLCN voltage-gated chloride channel genes in human blood vessels". J. Mol. Cell. Cardiol. 31 (3): 657–66. 1999. doi:10.1006/jmcc.1998.0901. PMID 10198195. 
• "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. 2000. doi:10.1101/gr.143000. PMID 11076863. 
• "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase". J. Biol. Chem. 276 (23): 20093–100. 2001. doi:10.1074/jbc.M009376200. PMID 11274166. 
• "Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium". Am. J. Respir. Cell Mol. Biol. 24 (4): 376–81. 2001. doi:10.1165/ajrcmb.24.4.4114. PMID 11306429. 
• "ClC-3B, a novel ClC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC". FASEB J. 16 (8): 863–5. 2002. doi:10.1096/fj.01-0845fje. PMID 11967229. 
• "ClC-3 is a fundamental molecular component of volume-sensitive outwardly rectifying Cl- channels and volume regulation in HeLa cells and Xenopus laevis oocytes". J. Biol. Chem. 277 (42): 40066–74. 2002. doi:10.1074/jbc.M205132200. PMID 12183454. 
• "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins". J. Biol. Chem. 278 (8): 6440–9. 2003. doi:10.1074/jbc.M211050200. PMID 12471024. 
• "Fundamental role of ClC-3 in volume-sensitive Cl- channel function and cell volume regulation in AGS cells". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (5): G938-48. 2003. doi:10.1152/ajpgi.00470.2002. PMID 12842831. 
• "Expression of voltage-gated chloride channels in human glioma cells". J. Neurosci. 23 (13): 5572–82. 2003. doi:10.1523/JNEUROSCI.23-13-05572.2003. PMID 12843258. 
• "AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells". J. Biol. Chem. 279 (24): 25430–9. 2004. doi:10.1074/jbc.M402331200. PMID 15073168. 
• "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336. 
• "Regulation of intracellular Cl- concentration through volume-regulated ClC-3 chloride channels in A10 vascular smooth muscle cells". J. Biol. Chem. 280 (8): 7301–8. 2005. doi:10.1074/jbc.M412813200. PMID 15596438. 
• "Chloride channels in physiological volume regulation of human spermatozoa". Biol. Reprod. 73 (5): 1057–63. 2005. doi:10.1095/biolreprod.105.044123. PMID 16033995. 
• "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. 2006. doi:10.1093/nar/gkj139. PMID 16381901. 

External links

• CLCN3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CLCN3 genome location and CLCN3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.