Biology:ABLIM3

Generic protein structure example

Actin-binding LIM protein 3 is a protein that in humans is encoded by the ABLIM3 gene.

Function

The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins, such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer. An important paralog of this gene is LIMS1.

Clinical relevance

Diseases associated with ABLIM3 include hepatoblastoma, and among its related super-pathways are axon guidance and DCC mediated attractive signaling.

External links

• Human ABLIM3 genome location and ABLIM3 gene details page in the UCSC Genome Browser.

Further reading

• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (6): 355–64. Dec 1998. doi:10.1093/dnares/5.6.355. PMID 10048485. 
• "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. Nov 2000. doi:10.1101/gr.143000. PMID 11076863. 
• "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. Mar 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene 23 (35): 5901–5911. Aug 2004. doi:10.1038/sj.onc.1207782. PMID 15221005. 
• "hhLIM protein is involved in cardiac hypertrophy". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1690 (1): 1–10. Sep 2004. doi:10.1016/j.bbadis.2004.04.009. PMID 15337165. 
• "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. Sep 2004. doi:10.1101/gr.2435604. PMID 15342556. 
• "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. Oct 2004. doi:10.1101/gr.2576704. PMID 15489336. 
• "Actin binding LIM protein 3 (abLIM3)". International Journal of Molecular Medicine 17 (1): 129–33. Jan 2006. doi:10.3892/ijmm.17.1.129. PMID 16328021. http://www.spandidos-publications.com/ijmm/17/1/129/download. 
• "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415–8. Jan 2006. doi:10.1093/nar/gkj139. PMID 16381901. 
• "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. Nov 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• "Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin". The Journal of Biological Chemistry 282 (11): 8393–8403. Mar 2007. doi:10.1074/jbc.M607549200. PMID 17194709.