Biology:ACOT7
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.[1][2][3][4]
This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized.[4]
References
- ↑ "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem 126 (6): 1013–9. Mar 2000. doi:10.1093/oxfordjournals.jbchem.a022544. PMID 10578051.
- ↑ "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res 46 (9): 2029–32. Aug 2005. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
- ↑ "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J 20 (11): 1855–64. Aug 2006. doi:10.1096/fj.06-6042com. PMID 16940157. https://arrow.dit.ie/scschbioart/11.
- ↑ 4.0 4.1 "Entrez Gene: ACOT7 acyl-CoA thioesterase 7". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11332.
External links
- Human ACOT7 genome location and ACOT7 gene details page in the UCSC Genome Browser.
Further reading
- Yamada J (2006). "Long-chain acyl-CoA hydrolase in the brain.". Amino Acids 28 (3): 273–8. doi:10.1007/s00726-005-0181-1. PMID 15731883.
- "Human brain acyl-CoA hydrolase isoforms encoded by a single gene.". Biochem. Biophys. Res. Commun. 299 (1): 49–56. 2003. doi:10.1016/S0006-291X(02)02587-1. PMID 12435388.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy". Amino Acids 27 (3–4): 269–75. 2005. doi:10.1007/s00726-004-0138-9. PMID 15592755.
- "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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