Biology:ACSL3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Long-chain-fatty-acid—CoA ligase 3 is an enzyme that in humans is encoded by the ACSL3 gene.[1]
Function
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.[1]
References
External links
- Human ACSL3 genome location and ACSL3 gene details page in the UCSC Genome Browser.
Further reading
- "The mapping of a gene for craniosynostosis: evidence for linkage of the Saethre-Chotzen syndrome to distal chromosome 7p". Journal of Medical Genetics 29 (10): 681–685. Oct 1992. doi:10.1136/jmg.29.10.681. PMID 1433226.
- "Identity between palmitoyl-CoA synthetase and arachidonoyl-CoA synthetase in human platelet?". The Biochemical Journal 274 ( Pt 1) (1): 145–52. Feb 1991. doi:10.1042/bj2740145. PMID 1848073.
- "Acyl-CoA synthetase and the peroxisomal enzymes of beta-oxidation in human liver. Quantitative analysis of their subcellular localization". The Biochemical Journal 224 (3): 709–20. Dec 1984. doi:10.1042/bj2240709. PMID 6240978.
- "Localization of the genetic locus for Saethre-Chotzen syndrome to a 6 cM region of chromosome 7 using four cases with apparently balanced translocations at 7p21.2". Human Molecular Genetics 3 (8): 1405–1408. Aug 1994. doi:10.1093/hmg/3.8.1405. PMID 7987323.
- "Molecular characterization and expression of rat acyl-CoA synthetase 3". The Journal of Biological Chemistry 271 (28): 16748–16752. Jul 1996. doi:10.1074/jbc.271.28.16748. PMID 8663269.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. Sep 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35". Genomics 42 (1): 180–181. May 1997. doi:10.1006/geno.1997.4710. PMID 9177793.
- "Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene". Gene 278 (1–2): 185–192. Oct 2001. doi:10.1016/S0378-1119(01)00714-4. PMID 11707336.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–16903. Dec 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family". Journal of Lipid Research 45 (10): 1958–1961. Oct 2004. doi:10.1194/jlr.E400002-JLR200. PMID 15292367.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–12135. Aug 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells". FEBS Letters 577 (3): 451–454. Nov 2004. doi:10.1016/j.febslet.2004.10.044. PMID 15556626.
- "UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man". Biology of Reproduction 74 (4): 644–651. Apr 2006. doi:10.1095/biolreprod.105.046698. PMID 16354793.
- "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Molecular & Cellular Proteomics 6 (4): 575–588. Apr 2007. doi:10.1074/mcp.M600249-MCP200. PMID 17220478. http://www.mcponline.org/content/6/4/575.full.pdf.
- "Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation". Arteriosclerosis, Thrombosis, and Vascular Biology 27 (10): 2198–2205. Oct 2007. doi:10.1161/ATVBAHA.107.148429. PMID 17761945.
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