Biology:ACSL6
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Acyl-CoA synthetase long-chain family member 6 is an enzyme that in humans is encoded by the ACSL6 gene.[1][2][3] Long-chain acyl-CoA synthetases such as ACSL6, catalyze the formation of acyl-CoA from fatty acids, ATP, and CoA.[2]
Structure
The ACSL6 gene is located on the 5th chromosome, with its specific location being 5q31.1. The gene contains 23 exons.[1] ACSL6 encodes a 77.7 kDa protein that is composed of 697 amino acids; 10 peptides have been observed through mass spectrometry data.[4][5]
References
- ↑ 1.0 1.1 "Entrez Gene: acyl-CoA synthetase long-chain family member 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23305.
- ↑ 2.0 2.1 "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors". Biochem. J. 344 Pt 1 (Pt 1): 135–43. November 1999. doi:10.1042/0264-6021:3440135. PMID 10548543.
- ↑ "Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)". Genes Chromosomes Cancer 26 (3): 192–202. November 1999. doi:10.1002/(SICI)1098-2264(199911)26:3<192::AID-GCC2>3.0.CO;2-E. PMID 10502316.
- ↑ ]"Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research 113 (9): 1043–53. Oct 2013. doi:10.1161/CIRCRESAHA.113.301151. PMID 23965338.
- ↑ "Long-chain-fatty-acid--CoA ligase 6". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). http://www.heartproteome.org/copa/ProteinInfo.aspx?QType=Protein%20ID&QValue=QQ9UKU0.[yes|permanent dead link|dead link}}]
External links
- Human ACSL6 genome location and ACSL6 gene details page in the UCSC Genome Browser.
Further reading
- "Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains". BMC Mol. Biol. 7: 21. 2006. doi:10.1186/1471-2199-7-21. PMID 16834775.
- "Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure". Fertil. Steril. 91 (4 Suppl): 1339–43. 2009. doi:10.1016/j.fertnstert.2008.03.035. PMID 18555221.
- "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. 1998. doi:10.1093/dnares/5.6.355. PMID 10048485.
- "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis 191 (1): 63–72. 2007. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
- "Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family". J. Lipid Res. 45 (10): 1958–61. 2004. doi:10.1194/jlr.E400002-JLR200. PMID 15292367.
- "t(5;12)(q23-31;p13) with ETV6-ACSL6 gene fusion in polycythemia vera". Leukemia 20 (6): 1175–8. 2006. doi:10.1038/sj.leu.2404194. PMID 16572202.
- "Association of haplotypes spanning PDZ-GEF2, LOC728637 and ACSL6 with schizophrenia in Han Chinese". J. Med. Genet. 45 (12): 818–26. 2008. doi:10.1136/jmg.2008.060657. PMID 18718982.
- "Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia". Hum. Mol. Genet. 15 (22): 3329–42. 2006. doi:10.1093/hmg/ddl409. PMID 17030554.
- "Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. 2007. doi:10.1101/gr.5660607. PMID 17567994.
- "Interaction between Interleukin 3 and Dystrobrevin-Binding Protein 1 in Schizophrenia". Schizophr. Res. 106 (2–3): 208–17. 2008. doi:10.1016/j.schres.2008.07.022. PMID 18804346.
- "DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia". Genes Brain Behav. 6 (3): 229–39. 2007. doi:10.1111/j.1601-183X.2006.00251.x. PMID 16827919.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Polymorphisms in mitochondrial genes and prostate cancer risk". Cancer Epidemiol. Biomarkers Prev. 17 (12): 3558–66. 2008. doi:10.1158/1055-9965.EPI-08-0434. PMID 19064571.
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