Biology:ACTL7A
 Generic protein structure example |
Actin-like protein 7A is a protein that in humans is encoded by the ACTL7A gene.[1][2]
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known.[2]
References
- ↑ "Cloning, mapping, and expression of two novel actin genes, actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31". Genomics 58 (3): 302–9. Jul 1999. doi:10.1006/geno.1999.5848. PMID 10373328.
- ↑ 2.0 2.1 "Entrez Gene: ACTL7A actin-like 7A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10881.
External links
- Human ACTL7A genome location and ACTL7A gene details page in the UCSC Genome Browser.
Further reading
- "Actin-related proteins.". Annu. Rev. Cell Dev. Biol. 15: 341–63. 2000. doi:10.1146/annurev.cellbio.15.1.341. PMID 10611965.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions.". J. Cell Biol. 161 (1): 33–9. 2003. doi:10.1083/jcb.200211015. PMID 12695497.
- "TES is a novel focal adhesion protein with a role in cell spreading.". J. Cell Sci. 116 (Pt 5): 897–906. 2003. doi:10.1242/jcs.00278. PMID 12571287.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
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