Biology:AGXT2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
The human AGXT2 gene encodes the protein Alanine—glyoxylate aminotransferase 2. [1]
Function
The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor.[2]
References
- ↑ "Entrez Gene: Alanine--glyoxylate aminotransferase 2". https://www.ncbi.nlm.nih.gov/gene/64902.
- ↑ [provided by RefSeq, Dec 2008]. ##Evidence-Data-START## Transcript exon combination :: AJ292204.1, AB193309.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025084, ERS025088 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##
Further reading
- "Molecular cloning and sequencing of a cDNA encoding alanine-glyoxylate aminotransferase 2 from rat kidney". Journal of Biochemistry 117 (4): 856–862. April 1995. doi:10.1093/oxfordjournals.jbchem.a124787. PMID 7592550.
- Barsh, Gregory S, ed (September 2011). "A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection". PLOS Genetics 7 (9): e1002270. doi:10.1371/journal.pgen.1002270. PMID 21931564.
- "A genome-wide association study of metabolic traits in human urine". Nature Genetics 43 (6): 565–569. June 2011. doi:10.1038/ng.837. PMID 21572414.
- "Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production". The Journal of Biological Chemistry 285 (8): 5385–5391. February 2010. doi:10.1074/jbc.M109.091280. PMID 20018850.
- "Glycolate and glyoxylate metabolism in HepG2 cells". American Journal of Physiology. Cell Physiology 287 (5): C1359–C1365. November 2004. doi:10.1152/ajpcell.00238.2004. PMID 15240345.
- "Primary hyperoxaluria: from gene defects to designer drugs?". Nephrology, Dialysis, Transplantation 20 (8): 1525–1529. August 2005. doi:10.1093/ndt/gfh923. PMID 15956068.
- "Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure". Arteriosclerosis, Thrombosis, and Vascular Biology 32 (12): 2892–2900. December 2012. doi:10.1161/ATVBAHA.112.254078. PMID 23023372.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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