Biology:ALDH3B1
 Generic protein structure example |
Aldehyde dehydrogenase 3 family, member B1 also known as ALDH3B1 is an enzyme that in humans is encoded by the ALDH3B1 gene.[1][2]
Function
The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular gene spans about 20 kb of genomic DNA and is composed of 9 coding exons. The gene encodes a single transcript of 2.8 kb that is highly expressed in kidney and lung. The functional significance of this gene and the cellular localization of its product are presently unknown. Two transcript variants encoding different isoforms have been found for this gene.[3]
Model organisms
Model organisms have been used in the study of ALDH3B1 function. A conditional knockout mouse line called Aldh3b1tm1b(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[4] Male and female animals underwent a standardized phenotypic screen[5] to determine the effects of deletion.[6][7][8][9] Additional screens performed: - In-depth immunological phenotyping[10] - in-depth bone and cartilage phenotyping[11]
| Characteristic | Phenotype |
|---|---|
| All data available at.[5][10][11] | |
| Peripheral blood leukocytes 6 Weeks | Normal |
| Haematology 6 Weeks | Normal |
| Insulin | Normal |
| Homozygous viability at P14 | Abnormal |
| Homozygous Fertility | Normal |
| Body weight | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology 16 Weeks | Normal |
| Peripheral blood leukocytes 16 Weeks | Normal |
| Heart weight | Normal |
| Salmonella infection | Normal |
| Cytotoxic T Cell Function | Normal |
| Epidermal Immune Composition | Normal |
References
- ↑ "Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family". Gene 151 (1–2): 285–9. Dec 1994. doi:10.1016/0378-1119(94)90672-6. PMID 7828891.
- ↑ "Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison". Gene 189 (1): 89–94. Apr 1997. doi:10.1016/S0378-1119(96)00839-6. PMID 9161417.
- ↑ "Entrez Gene: ALDH3B1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=221.
- ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ 5.0 5.1 "International Mouse Phenotyping Consortium". http://www.mousephenotype.org/data/search?q=Aldh3b1#fq=*:*&facet=gene.
- ↑ "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. Jun 2011. doi:10.1038/nature10163. PMID 21677750.
- ↑ "Mouse library set to be knockout". Nature 474 (7351): 262–3. Jun 2011. doi:10.1038/474262a. PMID 21677718.
- ↑ "A mouse for all reasons". Cell 128 (1): 9–13. Jan 2007. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. 2013. doi:10.1016/j.cell.2013.06.022. PMID 23870131.
- ↑ 10.0 10.1 "Infection and Immunity Immunophenotyping (3i) Consortium". http://www.immunophenotyping.org/data/search?keys=Aldh3b1&field_gene_construct_tid=All.
- ↑ 11.0 11.1 "OBCD Consortium". http://www.boneandcartilage.com/.
External links
- Human ALDH3B1 genome location and ALDH3B1 gene details page in the UCSC Genome Browser.
Further reading
- "Multi-locus association study of schizophrenia susceptibility genes with a posterior probability method". Science in China Series C: Life Sciences 48 (3): 263–9. Jun 2005. doi:10.1007/bf03183620. PMID 16092759.
- "Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family". Gene 151 (1–2): 285–9. Dec 1994. doi:10.1016/0378-1119(94)90672-6. PMID 7828891.
- "Expression and initial characterization of human ALDH3B1". Biochemical and Biophysical Research Communications 356 (3): 792–8. May 2007. doi:10.1016/j.bbrc.2007.03.046. PMID 17382292.
- "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects". Journal of Human Genetics 54 (6): 317–23. Jun 2009. doi:10.1038/jhg.2009.31. PMID 19343046.
- "Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia". Biological Psychiatry 65 (12): 1048–54. Jun 2009. doi:10.1016/j.biopsych.2008.11.027. PMID 19159868.
- "Human aldehyde dehydrogenase gene family". European Journal of Biochemistry / FEBS 251 (3): 549–57. Feb 1998. doi:10.1046/j.1432-1327.1998.2510549.x. PMID 9490025.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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