Biology:AMY2B
From HandWiki
Generic protein structure example |
Alpha-amylase 2B is an enzyme that in humans is encoded by the AMY2B gene.[1][2]
Function
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside] bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.[2]
References
- ↑ "Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1203 (2): 224–9. December 1993. doi:10.1016/0167-4838(93)90087-8. PMID 8268204.
- ↑ 2.0 2.1 "Entrez Gene: AMY2B amylase, alpha 2B (pancreatic)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=280.
External links
- Human AMY2B genome location and AMY2B gene details page in the UCSC Genome Browser.
Further reading
- "The action of human pancreatic and salivary isoamylases on starch and glycogen". Clinica Chimica Acta; International Journal of Clinical Chemistry 79 (1): 69–73. August 1977. doi:10.1016/0009-8981(77)90462-4. PMID 890964.
- "Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers". Genomics 8 (1): 97–105. September 1990. doi:10.1016/0888-7543(90)90230-R. PMID 2081604.
- "Cloning and characterization of a third type of human alpha-amylase gene, AMY2B". Gene 90 (2): 281–6. June 1990. doi:10.1016/0378-1119(90)90191-S. PMID 2401405.
- "Concerted evolution of human amylase genes". Molecular and Cellular Biology 8 (3): 1197–205. March 1988. doi:10.1128/mcb.8.3.1197. PMID 2452973.
- "Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene". Nucleic Acids Research 16 (17): 8261–76. September 1988. doi:10.1093/nar/16.17.8261. PMID 2458567.
- "A novel type of human alpha-amylase produced in lung carcinoid tumor". Gene 76 (1): 11–8. March 1989. doi:10.1016/0378-1119(89)90003-6. PMID 2701942.
- "The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes". Genomics 5 (1): 29–42. July 1989. doi:10.1016/0888-7543(89)90083-9. PMID 2788608.
- "Human pancreatic amylase is encoded by two different genes". Nucleic Acids Research 16 (10): 4724. May 1988. doi:10.1093/nar/16.10.4724. PMID 3260028.
- "Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1". Somatic Cell and Molecular Genetics 10 (2): 205–10. March 1984. doi:10.1007/BF01534909. PMID 6608795.
- "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 8 (2): 85–95. April 2001. doi:10.1093/dnares/8.2.85. PMID 11347906.
- "A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas". Saudi Medical Journal 22 (5): 410–5. May 2001. PMID 11376382.
- "alpha-Amylase expressed in human liver is encoded by the AMY-2B gene identified in tumorous tissues". Clinica Chimica Acta; International Journal of Clinical Chemistry 309 (1): 73–83. July 2001. doi:10.1016/S0009-8981(01)00501-0. PMID 11408008.
- "Detection of large-scale variation in the human genome". Nature Genetics 36 (9): 949–51. September 2004. doi:10.1038/ng1416. PMID 15286789.