Biology:ARID4B
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Short description: Protein
 Generic protein structure example |
AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene.[1][2]
Function
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.[2]
References
- ↑ "RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis". J Natl Cancer Inst 93 (15): 1159–65. Aug 2001. doi:10.1093/jnci/93.15.1159. PMID 11481388.
- ↑ 2.0 2.1 "Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51742.
External links
- Human ARID4B genome location and ARID4B gene details page in the UCSC Genome Browser.
Further reading
- "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. 2002. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease.". J. Cell Biol. 159 (4): 563–9. 2003. doi:10.1083/jcb.200208001. PMID 12446740.
- "Identification and characterization of three new components of the mSin3A corepressor complex.". Mol. Cell. Biol. 23 (10): 3456–67. 2003. doi:10.1128/MCB.23.10.3456-3467.2003. PMID 12724404.
- "Characterization of BRCAA1 and its novel antigen epitope identification.". Cancer Epidemiol. Biomarkers Prev. 13 (7): 1136–45. 2004. PMID 15247124.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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