Biology:ATP11C
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Short description: Protein-coding gene in humans
 Generic protein structure example |
ATP11C is an enzyme that in humans is encoded by the ATP11C gene.
Function
ATP11C encodes a member of the Type IV P-type ATPase family that is thought to transport or 'flip' aminophospholipids. The corresponding protein in mice is essential for the development of B cells and red blood cells,[1][2] and for the prevention of intrahepatic cholestasis.[3]
References
- ↑ "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology 12 (5): 434–40. May 2011. doi:10.1038/ni.2012. PMID 21423172.
- ↑ "ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes". Nature Immunology 12 (5): 441–9. May 2011. doi:10.1038/ni.2011. PMID 21423173.
- ↑ "X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C". Proceedings of the National Academy of Sciences of the United States of America 108 (19): 7890–5. May 2011. doi:10.1073/pnas.1104631108. PMID 21518881. Bibcode: 2011PNAS..108.7890S.
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