Biology:Adhesion molecule (immunoglobulin-like)

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Adhes-Ig_like
PDB 1gsm EBI.jpg
a reassessment of the madcam-1 structure and its role in integrin recognition.
Identifiers
SymbolAdhes-Ig_like
PfamPF09085
Pfam clanCL0011
InterProIPR015169
SCOP21gsm / SCOPe / SUPFAM

In molecular biology, the adhesin molecule (immunoglobulin-like) is a protein domain. This domain is found in mucosal vascular addressin cell adhesion molecule 1 proteins (MAdCAM-1). These are cell adhesion molecules expressed on the endothelium in mucosa that guide the specific homing of lymphocytes into mucosal tissues. MAdCAM-1 belongs to a subclass of the immunoglobulin superfamily (IgSF), the members of which are ligands for integrins.[1] The crystal structure of this domain has been reported; it adopts an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology.[1][2]

See also

References

  1. 1.0 1.1 "The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition". Structure 6 (6): 793–801. June 1998. doi:10.1016/S0969-2126(98)00080-X. PMID 9655832. 
  2. "A reassessment of the MAdCAM-1 structure and its role in integrin recognition". Acta Crystallogr. D 58 (Pt 2): 233–41. February 2002. doi:10.1107/S0907444901020522. PMID 11807247. http://journals.iucr.org/d/issues/2002/02/00/ad0159/ad0159.pdf. 
This article incorporates text from the public domain Pfam and InterPro: IPR015169