Biology:Alanine—oxo-acid transaminase
From HandWiki
Short description: Enzyme within the transanimase family
alanine-oxo-acid transaminase | |||||||||
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Identifiers | |||||||||
EC number | 2.6.1.12 | ||||||||
CAS number | 9030-41-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an alanine-oxo-acid transaminase (EC 2.6.1.12) is an enzyme that catalyzes the chemical reaction
- L-alanine + a 2-oxo acid [math]\displaystyle{ \rightleftharpoons }[/math] pyruvate + an L-amino acid
Thus, the two substrates of this enzyme are L-alanine and 2-oxo acid, whereas its two products are pyruvate and L-amino acid.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-alanine:2-oxo-acid aminotransferase. Other names in common use include L-alanine-alpha-keto acid aminotransferase, leucine-alanine transaminase, alanine-keto acid aminotransferase, and alanine-oxo acid aminotransferase. This enzyme participates in alanine and aspartate metabolism. It employs one cofactor, pyridoxal phosphate.
References
- "Transaminases in smooth Brucella abortus, strain 19" (PDF). J. Biol. Chem. 204 (1): 159–67. 1953. PMID 13084587. http://www.jbc.org/content/204/1/159.full.pdf.
- Rowsell EV (1956). "Transaminations with pyruvate and other alpha-keto acids". Biochem. J. 64 (2): 246–252. PMID 13363834.
- Sallach HJ (1956). "Formation of serine from hydroxypyruvate and L-alanine" (PDF). J. Biol. Chem. 223 (2): 1101–1108. http://www.jbc.org/content/223/2/1101.full.pdf.
- "Transaminase reactions in plants" (PDF). J. Biol. Chem. 208 (2): 863–874. 1954. http://www.jbc.org/content/208/2/863.full.pdf.
Original source: https://en.wikipedia.org/wiki/Alanine—oxo-acid transaminase.
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