Biology:Aliphatic aldoxime dehydratase

From HandWiki
Aliphatic aldoxime dehydratase
Identifiers
EC number4.99.1.5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

In enzymology, an aliphatic aldoxime dehydratase (EC 4.99.1.5) is an enzyme that catalyzes the chemical reaction

an aliphatic aldoxime [math]\displaystyle{ \rightleftharpoons }[/math] an aliphatic nitrile + H2O

This dehydratase converts an aldoxime on an aliphatic substrate to a nitrile as the product structure with water as byproduct.

This enzyme belongs to the family of lyases, specifically the "catch-all" class of lyases that do not fit into any other sub-class. The systematic name of this enzyme class is aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming). Other names in common use include OxdA, and aliphatic aldoxime hydro-lyase.

See also

  • D-amino acid oxidase, sometimes also referred to as OXDA

References

  • Kobayashi M; Hashimoto, Y; Konishi, K; Goda, M; Noguchi, T; Higashibata, H; Kobayashi, M (2003). "Novel aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis of Pseudomonas chlororaphis B23. Sequencing, gene expression, purification, and characterization". J. Biol. Chem. 278 (32): 29600–8. doi:10.1074/jbc.M211832200. PMID 12773527. 
  • "A gene cluster responsible for alkylaldoxime metabolism coexisting with nitrile hydratase and amidase in Rhodococcus globerulus A-4". Biochemistry 42 (41): 12056–66. 2003. doi:10.1021/bi035092u. PMID 14556637. 
  • "Aldoxime dehydratase co-existing with nitrile hydratase and amidase in the iron-type nitrile hydratase-producer Rhodococcus sp. N-771". J. Biosci. Bioeng. 97 (4): 250–9. 2004. doi:10.1016/S1389-1723(04)70200-5. PMID 16233624.