Biology:AspS RNA motif
| aspS | |
|---|---|
 Consensus secondary structure and sequence conservation of aspS RNA | |
| Identifiers | |
| Symbol | aspS |
| Rfam | RF02930 |
| Other data | |
| RNA type | Cis-reg |
| SO | 0005836 |
| PDB structures | PDBe |
The aspS RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] aspS motifs are found in a specific lineage of Actinomycetota.
aspS motif RNAs likely function as cis-regulatory elements, in view of their positions upstream of protein-coding genes. Instances of the aspS RNA motif are often located nearby to the predicted Shine-Dalgarno sequence of the downstream gene. This arrangement is consistent with a model of cis-regulation where the RNA allosterically controls access to the Shine-Dalgarno sequence, thus regulating the gene translationally.
aspS genes encode aminoacyl tRNA synthetases. T-box leader RNAs detect low levels of various amino acids, and regulate genes in a cis-regulatory manner. Genes regulated by T-box RNAs often include aminoacyl tRNA synthetases. It is possible that aspS RNAs are diverged examples of T-box RNAs, or they might implement a different structural solution to the same biological problem.
References
- ↑ "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. October 2017. doi:10.1093/nar/gkx699. PMID 28977401.
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