Biology:BAZ1A
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
Bromodomain adjacent to zinc finger domain protein 1A is a protein that in humans is encoded by the BAZ1A gene.[1][2]
Structure
The protein encoded by this gene belongs to a family of proteins which includes BAZ1B, BAZ2A, and BAZ2B. All family members contain the following domains and structural motifs:[1]
- N-terminus – PHD finger (C4HC3 zinc finger)
- WAKZ motif
- LH (leucine-rich helical domain) motif
- C-terminus – bromodomain
Function
BAZ1A along with SMARCA5, POLE3, and CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex.[3][4]
The purified CHRAC complex can mobilize nucleosomes into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent.[4] Furthermore, the BAZ1A-SMARCA5 complex enables DNA replication through highly condensed regions of chromatin.[5]
Interactions
BAZ1A has been shown to interact with SMARCA5[3][4][6][7][8] and SATB1.[7]
References
- ↑ 1.0 1.1 "A novel family of bromodomain genes". Genomics 63 (1): 40–5. Apr 2000. doi:10.1006/geno.1999.6071. PMID 10662543.
- ↑ "Entrez Gene: BAZ1A bromodomain adjacent to zinc finger domain, 1A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11177.
- ↑ 3.0 3.1 "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1038–43. February 2000. doi:10.1073/pnas.97.3.1038. PMID 10655480. Bibcode: 2000PNAS...97.1038B.
- ↑ 4.0 4.1 4.2 "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. July 2000. doi:10.1093/emboj/19.13.3377. PMID 10880450.
- ↑ "An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin". Nat. Genet. 32 (4): 627–32. December 2002. doi:10.1038/ng1046. PMID 12434153.
- ↑ Bozhenok, Ludmila; Wade Paul A; Varga-Weisz Patrick (May 2002). "WSTF–ISWI chromatin remodeling complex targets heterochromatic replication foci". EMBO J. (England) 21 (9): 2231–41. doi:10.1093/emboj/21.9.2231. ISSN 0261-4189. PMID 11980720.
- ↑ 7.0 7.1 Yasui, Dag; Miyano Masaru; Cai Shutao; Varga-Weisz Patrick; Kohwi-Shigematsu Terumi (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature (England) 419 (6907): 641–5. doi:10.1038/nature01084. ISSN 0028-0836. PMID 12374985. Bibcode: 2002Natur.419..641Y. https://digital.library.unt.edu/ark:/67531/metadc733622/.
- ↑ Hakimi, Mohamed-Ali; Bochar Daniel A; Schmiesing John A; Dong Yuanshu; Barak Orr G; Speicher David W; Yokomori Kyoko; Shiekhattar Ramin (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature (England) 418 (6901): 994–8. doi:10.1038/nature01024. ISSN 0028-0836. PMID 12198550. Bibcode: 2002Natur.418..994H.
 |  |
