Biology:BCAR3
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 Generic protein structure example |
Breast cancer anti-estrogen resistance protein 3 is a protein that in humans is encoded by the BCAR3 gene.[1][2]
Function
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hallmark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.[2]
References
- ↑ "Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells". EMBO J 17 (10): 2799–808. Jul 1998. doi:10.1093/emboj/17.10.2799. PMID 9582273.
- ↑ 2.0 2.1 "Entrez Gene: BCAR3 breast cancer anti-estrogen resistance 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8412.
External links
- Human BCAR3 genome location and BCAR3 gene details page in the UCSC Genome Browser.
Further reading
- "Genetic mechanisms of estrogen-independence in breast cancer.". Pathol. Res. Pract. 192 (7): 743–51. 1997. doi:10.1016/S0344-0338(96)80096-3. PMID 8880875.
- Johnston SR (1998). "Acquired tamoxifen resistance in human breast cancer--potential mechanisms and clinical implications.". Anticancer Drugs 8 (10): 911–30. doi:10.1097/00001813-199711000-00002. PMID 9436634.
- "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway.". J. Biol. Chem. 274 (15): 10047–52. 1999. doi:10.1074/jbc.274.15.10047. PMID 10187783.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42.". J. Immunol. 170 (2): 969–78. 2003. doi:10.4049/jimmunol.170.2.969. PMID 12517963.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway.". Breast Cancer Res. 7 (1): R82–92. 2006. doi:10.1186/bcr954. PMID 15642172.
- "AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner.". Mol. Cancer Res. 3 (1): 32–41. 2005. PMID 15671247.
- "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. 2006. doi:10.1038/nbt1240. PMID 16964243.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling.". Gene 391 (1–2): 161–70. 2007. doi:10.1016/j.gene.2006.12.016. PMID 17270363.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology.". J. Cell. Physiol. 212 (3): 655–65. 2007. doi:10.1002/jcp.21059. PMID 17427198.
- "Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling.". Cancer Res. 67 (13): 6174–82. 2007. doi:10.1158/0008-5472.CAN-06-3455. PMID 17616674.
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