Biology:BPIFB2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

BPI fold-containing family B, member 2, (BPIFB2) also known as bactericidal/permeability-increasing protein-like 1, (BPI-like 1) is a protein that in humans is encoded by the BPIFB2 gene.

Superfamily

BPIFB2 is a member of a BPI fold protein superfamily defined by the presence of the bactericidal/permeability-increasing protein fold (BPI fold) which is formed by two similar domains in a "boomerang" shape. This superfamily is also known as the BPI/LBP/PLUNC family or the BPI/LPB/CETP family. The BPI fold creates apolar binding pockets that can interact with hydrophobic and amphipathic molecules, such as the acyl carbon chains of lipopolysaccharide found on Gram-negative bacteria, but members of this family may have many other functions.

BPIFB2 is a member of the BPI-fold gene family and the BPI/LBP/PLUNC protein superfamily

Genes for the BPI/LBP/PLUNC superfamily are found in all vertebrate species, including distant homologs in non-vertebrate species such as insects, mollusks, and roundworms. Within that broad grouping is the BPIF gene family whose members encode the BPI fold structural motif and are found clustered on a single chromosome, e.g., Chromosome 20 in humans, Chromosome 2 in mouse, Chromosome 3 in rat, Chromosome 17 in pig, Chromosome 13 in cow. The BPIF gene family is split into two groupings, BPIFA and BPIFB. In humans, BIPFA consists of 3 protein encoding genes BPIFA1, BPIFA2, BPIFA3, and 1 pseudogene BPIFA4P; while BPIFB consists of 5 protein encoding genes BPIFB1, BPIFB2, BPIFB3, BPIFB4, BPIFB6 and 2 pseudogenes BPIFB5P, BPIFB9P. What appears as pseudogenes in humans may appear as fully functional genes in other species.

In humans, the BPIFB2 gene was first identified as a BPIL3 gene whose encoded protein was called LPLUNC2 (long-palate lung and nasal epithelium clone 2), but subsequently PLUNC proteins were classified as a subfamily of the BPI fold superfamily. In humans, the BPIFB2 gene is found with other members of the BPI/LBP/PLUNC superfamily in a cluster on Chromosome 20.

Function

The BPIFB2 protein is involved in the innate immune response to bacterial exposure in the mucosa of the mouth, nasal cavities, and lungs, like other closely related BPIFB proteins. In particular, it is highly expressed in normal salivary glands and esophagus as well as in hypertrophic tonsils in humans. In chronic rhinosinusitis BPIFB2/LPLUNC2 levels are profoundly reduced which has been interpreted as a defect in the release of glandular innate defense molecules.

External links

• Human BPIFB2 genome location and BPIFB2 gene details page in the UCSC Genome Browser.

Further reading

• "Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1493 (3): 363–367. October 2000. doi:10.1016/S0167-4781(00)00196-2. PMID 11018263. 
• "PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx". Human Molecular Genetics 11 (8): 937–943. April 2002. doi:10.1093/hmg/11.8.937. PMID 11971875. 
• "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science 13 (10): 2819–2824. October 2004. doi:10.1110/ps.04682504. PMID 15340161. 
• "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". Journal of Proteome Research 5 (6): 1493–1503. June 2006. doi:10.1021/pr050492k. PMID 16740002.