Biology:BRCT domain
| BRCA1 C Terminus (BRCT) domain | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Structure of an XRCC1 BRCT domain.[1] | |||||||||||
| Identifiers | |||||||||||
| Symbol | BRCT | ||||||||||
| Pfam | PF00533 | ||||||||||
| InterPro | IPR001357 | ||||||||||
| SCOP2 | 1cdz / SCOPe / SUPFAM | ||||||||||
| CDD | cd00027 | ||||||||||
| |||||||||||
BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins. It is named after the C-terminal domain of BRCA1, a DNA-repair protein that serves as a marker of breast cancer susceptibility.
The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage,[2] for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.[3]
Examples
Human proteins containing this domain include:
- BARD1; BRCA1
- CTDP1; TDT or DNTT
- ECT2
- LIG4
- MCPH1; MDC1
- NBN
- PARP1; PARP4; PAXIP1; PES1
- REV1; RFC1; TOPBP1; TP53BP1; XRCC1
References
- ↑ "Structure of an XRCC1 BRCT domain: a new protein-protein interaction module". EMBO J. 17 (21): 6404–11. November 1998. doi:10.1093/emboj/17.21.6404. PMID 9799248.
- ↑ "A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins". FASEB J. 11 (1): 68–76. 1997. doi:10.1096/fasebj.11.1.9034168. PMID 9034168.
- ↑ "The BRCT domain is a phospho-protein binding domain". Science 302 (5645): 639–642. 2003. doi:10.1126/science.1088753. PMID 14576433.
External links
- Eukaryotic Linear Motif resource motif class LIG_BRCT_BRCA1_1
- Eukaryotic Linear Motif resource motif class LIG_BRCT_BRCA1_2
- Eukaryotic Linear Motif resource motif class LIG_BRCT_MDC1_1
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