Biology:BTG1
 Generic protein structure example |
Protein BTG1 is a protein that in humans is encoded by the BTG1 gene.[1][2]
Function
The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. It is a member of a family of antiproliferative genes. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. It negatively regulates cell proliferation.[2]
Interactions
BTG1 has been shown to interact with:
Clinical relevance
Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[9][10]
Maintenance of adult neural stem cells
Recent data, obtained in a new model of mouse lacking the BTG1 gene, indicate that BTG1 is essential for the proliferation and expansion of stem cells in the adult neurogenic niches, i.e. the dentate gyrus and sub ventricular zone (see for review[11]). In particular, BTG1 keeps adult neural stem cells in quiescence, preserving the neural stem cells pool from depletion. In the absence of BTG1, the stem and progenitor cells initially hyper proliferate and then in the longer period lose the ability to proliferate and expand.[12][13] Other recent data indicate that physical exercise can fully reconstitute the proliferative defect of stem cells that follows the ablation of the BTG1 gene, suggesting that the pool of neural stem cells maintains a hidden form of plasticity which is tightly controlled by BTG1; hence, BTG1 might prevent the depletion of stem cells in the presence of strong neurogenic stimuli or of neural degenerative stimuli.[14][15]
Btg1 plays a role also in the expansion of cerebellar granule precursor cells. In fact the deletion of Btg1 leads in mouse to uncontrolled proliferation of the cerebellar precursor cells during the early postnatal period. Consequently, in the adult, the cerebellum lacking Btg1 is significantly larger and the motor coordination is heavily impaired.[16]
The closest homolog of BTG1 is BTG2, which also controls the proliferation and differentiation of adult neural stem cells; the role of BTG2, however, appears to differ from that of BTG1 being probably more relevant in controlling the terminal differentiation of neural stem and progenitor cells in the adult neurogenic niches.[13]
References
- ↑ "An anti-proliferative gene BTG1 regulates angiogenesis in vitro". Biochemical and Biophysical Research Communications 316 (3): 628–35. April 2004. doi:10.1016/j.bbrc.2004.02.095. PMID 15033446.
- ↑ 2.0 2.1 "Entrez Gene: BTG1 B-cell translocation gene 1, anti-proliferative". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=694.
- ↑ "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". The Biochemical Journal. 336 336 ( Pt 2) (2): 471–81. December 1998. doi:10.1042/bj3360471. PMID 9820826.
- ↑ 4.0 4.1 "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". The Journal of Biological Chemistry 276 (13): 9640–8. March 2001. doi:10.1074/jbc.M008201200. PMID 11136725.
- ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- ↑ "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". The Journal of Biological Chemistry 275 (1): 147–53. January 2000. doi:10.1074/jbc.275.1.147. PMID 10617598.
- ↑ "The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase". The Journal of Biological Chemistry 271 (25): 15034–44. June 1996. doi:10.1074/jbc.271.25.15034. PMID 8663146.
- ↑ "Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects". Genes to Cells 7 (1): 29–39. January 2002. doi:10.1046/j.1356-9597.2001.00497.x. PMID 11856371.
- ↑ "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma". Nature 476 (7360): 298–303. August 2011. doi:10.1038/nature10351. PMID 21796119. Bibcode: 2011Natur.476..298M.
- ↑ "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. March 2012. doi:10.1073/pnas.1121343109. PMID 22343534. Bibcode: 2012PNAS..109.3879L.
- ↑ "Control of the Normal and Pathological Development of Neural Stem and Progenitor Cells by the PC3/Tis21/Btg2 and Btg1 Genes - Review". Journal of Cellular Physiology 230 (12): 2881–90. December 2015. doi:10.1002/jcp.25038. PMID 25967096. http://www.inmm.cnr.it/tirone/pdfs/Btg1%20Btg2%20review%20Micheli%20Tirone%20J%20Cell%20Physiol%202015.pdf.
- ↑ "Btg1 is Required to Maintain the Pool of Stem and Progenitor Cells of the Dentate Gyrus and Subventricular Zone". Frontiers in Neuroscience 6: 124. 2012. doi:10.3389/fnins.2012.00124. PMID 22969701.
- ↑ 13.0 13.1 "Genetic control of adult neurogenesis: interplay of differentiation, proliferation and survival modulates new neurons function, and memory circuits - Review". Frontiers in Cellular Neuroscience 7: 59. 2013. doi:10.3389/fncel.2013.00059. PMID 23734097.
- ↑ "Running rescues defective adult neurogenesis by shortening the length of the cell cycle of neural stem and progenitor cells". Stem Cells 32 (7): 1968–82. July 2014. doi:10.1002/stem.1679. PMID 24604711.
- ↑ "Control of the cell cycle in adult neurogenesis and its relation with physical exercise - Review". Brain Plasticity 1 (1): 41–54. July 2015. doi:10.3233/BPL-150013. PMID 29765834.
- ↑ "Altered cerebellum development and impaired motor coordination in mice lacking the Btg1 gene: Involvement of cyclin D1". Developmental Biology 408 (1): 109–25. December 2015. doi:10.1016/j.ydbio.2015.10.007. PMID 26524254.
External links
- Human BTG1 genome location and BTG1 gene details page in the UCSC Genome Browser.
Further reading
- "BTG1, a member of a new family of antiproliferative genes". The EMBO Journal 11 (4): 1663–70. April 1992. doi:10.1002/j.1460-2075.1992.tb05213.x. PMID 1373383.
- "A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia". Genes, Chromosomes & Cancer 3 (1): 24–36. January 1991. doi:10.1002/gcc.2870030106. PMID 2069907.
- "Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human". Laboratory Investigation; A Journal of Technical Methods and Pathology 78 (7): 847–58. July 1998. PMID 9690562.
- "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". The Biochemical Journal. 336 336 ( Pt 2) (2): 471–81. December 1998. doi:10.1042/bj3360471. PMID 9820826.
- "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". The Journal of Biological Chemistry 275 (1): 147–53. January 2000. doi:10.1074/jbc.275.1.147. PMID 10617598.
- "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". The Journal of Biological Chemistry 276 (13): 9640–8. March 2001. doi:10.1074/jbc.M008201200. PMID 11136725.
- "Identification of functional domains involved in BTG1 cell localization". Oncogene 20 (21): 2691–703. May 2001. doi:10.1038/sj.onc.1204398. PMID 11420681.
- "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Japanese Journal of Cancer Research 92 (6): 592–6. June 2001. doi:10.1111/j.1349-7006.2001.tb01135.x. PMID 11429045.
- "Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects". Genes to Cells 7 (1): 29–39. January 2002. doi:10.1046/j.1356-9597.2001.00497.x. PMID 11856371.
- "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system". European Journal of Biochemistry 269 (14): 3596–604. July 2002. doi:10.1046/j.1432-1033.2002.03052.x. PMID 12135500.
- "FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1". The Journal of Cell Biology 164 (2): 175–84. January 2004. doi:10.1083/jcb.200307056. PMID 14734530.
- "Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation". Oncogene 24 (10): 1698–710. March 2005. doi:10.1038/sj.onc.1208373. PMID 15674337.
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