Biology:HOXB9

Short description: Protein-coding gene in humans

Generic protein structure example

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.

Function

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer.

Interactions

HOXB9 has been shown to interact with BTG2 and BTG1.

See also

• Homeobox

Further reading

• "Selective expression of two homeobox genes in CD34-positive cells from human bone marrow". Blood 78 (2): 323–8. 1991. doi:10.1182/blood.V78.2.323.323. PMID 1712647. 
• "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation 45 (1): 61–9. 1990. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366. 
• "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation 40 (3): 191–7. 1989. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724. 
• "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. 1989. doi:10.1093/nar/17.24.10385. PMID 2574852. 
• "Organization of human class I homeobox genes". Genome 31 (2): 745–56. 1989. doi:10.1139/g89-133. PMID 2576652. 
• "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. 1996. doi:10.1159/000134320. PMID 8646877. 
• "Modulation of homeobox B6 and B9 genes expression in human leukemia cell lines during myelomonocytic differentiation". Leuk. Lymphoma 31 (5–6): 599–608. 1998. doi:10.3109/10428199809057620. PMID 9922051. 
• "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. 2000. doi:10.1074/jbc.275.1.147. PMID 10617598. 
• "Altered HOX and WNT7A expression in human lung cancer". Proc. Natl. Acad. Sci. U.S.A. 97 (23): 12776–81. 2000. doi:10.1073/pnas.97.23.12776. PMID 11070089. Bibcode: 2000PNAS...9712776C. 
• "Clinical and experimental progression of a new model of human prostate cancer and therapeutic approach". Am. J. Pathol. 159 (2): 753–64. 2001. doi:10.1016/S0002-9440(10)61746-4. PMID 11485933. 
• "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Mol. Cell. Biol. 21 (21): 7509–22. 2001. doi:10.1128/MCB.21.21.7509-7522.2001. PMID 11585930. 
• "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. 2002. doi:10.1002/tera.10009. PMID 11857506. 
• "Differentiation of insulin-producing cells from human neural progenitor cells". PLOS Med. 2 (4): e103. 2005. doi:10.1371/journal.pmed.0020103. PMID 15839736. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560. 

External links

• HOXB9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.