Biology:Baculoviral IAP repeat-containing protein 3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Baculoviral IAP repeat-containing protein3 (also known as cIAP2) is a protein that in humans is encoded by the BIRC3 gene.[1][2]
cIAP2 is a member of the inhibitor of apoptosis family that inhibit apoptosis by interfering with the activation of caspases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The cIAP2 protein contains three BIR domains, a UBA domain, a CARD domain and a RING finger domain. Transcript variants encoding the same isoform have been identified.[3]
Interactions
Baculoviral IAP repeat-containing protein 3 has been shown to interact with:
References
- ↑ "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes". Nature 379 (6563): 349–53. February 1996. doi:10.1038/379349a0. PMID 8552191. Bibcode: 1996Natur.379..349L.
- ↑ "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins". Cell 83 (7): 1243–52. February 1996. doi:10.1016/0092-8674(95)90149-3. PMID 8548810.
- ↑ "Entrez Gene: BIRC3 baculoviral IAP repeat-containing 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=330.
- ↑ "IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases". EMBO J. 17 (8): 2215–23. 1998. doi:10.1093/emboj/17.8.2215. PMID 9545235.
- ↑ "cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination". Mol. Cell 30 (6): 689–700. 2008. doi:10.1016/j.molcel.2008.05.014. PMID 18570872.
- ↑ 6.0 6.1 "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. 16 (23): 6914–25. 1997. doi:10.1093/emboj/16.23.6914. PMID 9384571.
- ↑ 7.0 7.1 "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature 416 (6878): 345–7. 2002. doi:10.1038/416345a. PMID 11907583. Bibcode: 2002Natur.416..345L. https://zenodo.org/record/1233217.
- ↑ "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4974–8. 1996. doi:10.1073/pnas.93.10.4974. PMID 8643514. Bibcode: 1996PNAS...93.4974U.
- ↑ "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–20. 2000. doi:10.1074/jbc.275.15.11114. PMID 10753917.
- ↑ "Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment". J. Biol. Chem. 283 (46): 31633–40. 2008. doi:10.1074/jbc.M804753200. PMID 18784070.
Further reading
- "Genetic alterations underlying the pathogenesis of MALT lymphoma". Hematol. J. 3 (1): 10–3. 2003. doi:10.1038/sj.thj.6200146. PMID 11960389.
- "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4974–8. 1996. doi:10.1073/pnas.93.10.4974. PMID 8643514. Bibcode: 1996PNAS...93.4974U.
- "Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization". Genomics 37 (3): 404–6. 1997. doi:10.1006/geno.1996.0579. PMID 8938457.
- "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. 16 (23): 6914–25. 1998. doi:10.1093/emboj/16.23.6914. PMID 9384571.
- "IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases". EMBO J. 17 (8): 2215–23. 1998. doi:10.1093/emboj/17.8.2215. PMID 9545235.
- "Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2". Mamm. Genome 10 (1): 44–8. 1999. doi:10.1007/s003359900940. PMID 9892732.
- "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood 93 (10): 3418–31. 1999. doi:10.1182/blood.V93.10.3418.410k23_3418_3431. PMID 10233894.
- "API1-MALT1-MLT is involved in mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21)". Blood 94 (9): 3270–1. 1999. doi:10.1182/blood.V94.9.3270. PMID 10610122.
- "The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7". J. Biol. Chem. 275 (35): 26661–4. 2000. doi:10.1074/jbc.C000199200. PMID 10862606.
- "Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins". Cell 102 (1): 43–53. 2000. doi:10.1016/S0092-8674(00)00009-X. PMID 10929712.
- "Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type". Genes Chromosomes Cancer 29 (4): 281–91. 2001. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1036>3.0.CO;2-I. PMID 11066071.
- "Molecular characterization of CD40 signaling intermediates". J. Biol. Chem. 276 (46): 43334–42. 2001. doi:10.1074/jbc.M104994200. PMID 11562359.
- "A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death". Mol. Cell 8 (3): 613–21. 2001. doi:10.1016/S1097-2765(01)00341-0. PMID 11583623.
- "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature 416 (6878): 345–7. 2002. doi:10.1038/416345a. PMID 11907583. Bibcode: 2002Natur.416..345L. https://zenodo.org/record/1233217.
- "Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma". Carcinogenesis 23 (6): 1017–24. 2002. doi:10.1093/carcin/23.6.1017. PMID 12082024.
- "Reduced expression of the inhibitor of apoptosis proteins in T cells from patients with multiple sclerosis following interferon-beta therapy". J. Neuroimmunol. 129 (1–2): 224–31. 2002. doi:10.1016/S0165-5728(02)00185-6. PMID 12161039.
- "Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells". Exp. Cell Res. 279 (2): 277–90. 2002. doi:10.1006/excr.2002.5608. PMID 12243753.
External links
- Human BIRC3 genome location and BIRC3 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: Q13489 (Baculoviral IAP repeat-containing protein 3) at the PDBe-KB.
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