Biology:Brevican
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 Generic protein structure example |
Brevican core protein is a protein that in humans is encoded by the BCAN gene.[1][2][3] Brevican is a member of the lectican protein family.
Brevican is localised to the surface of neurons in the brain.[4] In melanocytic cells, BCAN gene expression may be regulated by MITF.[5]
References
- ↑ "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma". Gene 256 (1–2): 139–47. Oct 2000. doi:10.1016/S0378-1119(00)00362-0. PMID 11054543.
- ↑ "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23". Acta Medica Okayama 56 (1): 25–9. Feb 2002. PMID 11873941.
- ↑ "Entrez Gene: BCAN brevican". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63827.
- ↑ "Brevican: a key proteoglycan in the perisynaptic extracellular matrix of the brain". The International Journal of Biochemistry & Cell Biology 44 (7): 1051–4. Jul 2012. doi:10.1016/j.biocel.2012.03.022. PMID 22537913.
- ↑ "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research 21 (6): 665–76. Dec 2008. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
External links
- Human BCAN genome location and BCAN gene details page in the UCSC Genome Browser.
Further reading
- "The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility". The Journal of Biological Chemistry 283 (36): 24848–59. Sep 2008. doi:10.1074/jbc.M801433200. PMID 18611854.
- "Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms". The Journal of Biological Chemistry 270 (45): 27206–12. Nov 1995. doi:10.1074/jbc.270.45.27206. PMID 7592978.
- "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety". Proceedings of the National Academy of Sciences of the United States of America 94 (19): 10116–21. Sep 1997. doi:10.1073/pnas.94.19.10116. PMID 9294172. Bibcode: 1997PNAS...9410116A.
- "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites". The Journal of Biological Chemistry 275 (49): 38885–90. Dec 2000. doi:10.1074/jbc.M003875200. PMID 10986281.
- "The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding". The Journal of Biological Chemistry 276 (2): 1253–61. Jan 2001. doi:10.1074/jbc.M006783200. PMID 11038354.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research 13 (10): 2265–70. Oct 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis". Cancer Research 63 (18): 5685–90. Sep 2003. PMID 14522884.
- "Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets". Molecular and Cellular Neurosciences 24 (1): 148–59. Sep 2003. doi:10.1016/S1044-7431(03)00133-7. PMID 14550776.
- "Secreted brevican mRNA is expressed in the adult rat pituitary". Biochemical and Biophysical Research Communications 314 (3): 745–8. Feb 2004. doi:10.1016/j.bbrc.2003.12.151. PMID 14741698.
- "Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas". Cancer Research 65 (15): 6726–33. Aug 2005. doi:10.1158/0008-5472.CAN-05-0585. PMID 16061654.
- "Human glioblastomas overexpress ADAMTS-5 that degrades brevican". Acta Neuropathologica 110 (3): 239–46. Sep 2005. doi:10.1007/s00401-005-1032-6. PMID 16133547.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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