Biology:SIGLEC5

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. SIGLEC5 has also been designated CD170 (cluster of differentiation 170).

Further reading

• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33". Blood 92 (6): 2123–32. 1998. doi:10.1182/blood.V92.6.2123. PMID 9731071. 
• "OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily". J. Biol. Chem. 274 (32): 22729–38. 1999. doi:10.1074/jbc.274.32.22729. PMID 10428856. 
• "Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes". Gene 286 (2): 259–70. 2002. doi:10.1016/S0378-1119(02)00432-8. PMID 11943481. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes". Exp. Hematol. 31 (5): 382–8. 2003. doi:10.1016/S0301-472X(03)00046-8. PMID 12763136. 
• "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. 2004. doi:10.1038/nature02399. PMID 15057824. Bibcode: 2004Natur.428..529G. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation". J. Biol. Chem. 280 (20): 19843–51. 2005. doi:10.1074/jbc.M502041200. PMID 15769739. http://www.jbc.org/content/280/20/19843.full.pdf. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides". Biochemistry Mosc. 71 (5): 496–504. 2006. doi:10.1134/S0006297906050051. PMID 16732727. 
• "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors". Leuk. Res. 31 (2): 211–20. 2007. doi:10.1016/j.leukres.2006.05.026. PMID 16828866. 
• "Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates". FASEB J. 20 (12): 1964–73. 2006. doi:10.1096/fj.06-5800com. PMID 17012248. 
• "Structural Implications of Siglec-5-Mediated Sialoglycan Recognition". J. Mol. Biol. 375 (2): 437–47. 2007. doi:10.1016/j.jmb.2007.10.009. PMID 18022638. 

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Sialic acid-binding Ig-like lectin 5 (SIGLEC5)