Biology:Btz domain
From HandWiki
| Btz | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 structure of the human exon junction complex with a trapped dead-box helicase bound to rna | |||||||||
| Identifiers | |||||||||
| Symbol | Btz | ||||||||
| Pfam | PF09405 | ||||||||
| InterPro | IPR018545 | ||||||||
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In molecular biology, the Btz domain (CASC3/Barentsz eIF4AIII binding domain) is a protein domain found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.[1][2]
References
- ↑ "The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA". Cell 126 (4): 713–25. August 2006. doi:10.1016/j.cell.2006.08.006. PMID 16923391. https://www.dora.lib4ri.ch/psi/islandora/object/psi%3A16089.
- ↑ "An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay". Nature 427 (6976): 753–7. February 2004. doi:10.1038/nature02351. PMID 14973490.
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