Biology:CABLES1
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 Generic protein structure example |
CDK5 and ABL1 enzyme substrate 1 is a protein that in humans is encoded by the CABLES1 gene.[1][2]
CABLES1 is a cyclin-dependent kinase (CDK)-binding protein that plays a role in proliferation and/or cell differentiation (Zukerberg et al., 2004).[supplied by OMIM].[2] It is a tumor suppressor gene which losing it (by mutations, knockout, knockdown or inactivation) may lead to colorectal cancer CRC.[citation needed]
References
- ↑ "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A 99 (26): 16899–903. Dec 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- ↑ 2.0 2.1 "Entrez Gene: CABLES1 Cdk5 and Abl enzyme substrate 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91768.
External links
- Human CABLES1 genome location and CABLES1 gene details page in the UCSC Genome Browser.
Further reading
- "Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo.". Biochem. Biophys. Res. Commun. 273 (2): 442–7. 2000. doi:10.1006/bbrc.2000.2965. PMID 10873625.
- "Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.". Neuron 26 (3): 633–46. 2000. doi:10.1016/S0896-6273(00)81200-3. PMID 10896159. https://escholarship.org/content/qt9n91b7nv/qt9n91b7nv.pdf?t=nhv5i7.
- "ik3-1/Cables is associated with Trap and Pctaire2.". Biochem. Biophys. Res. Commun. 286 (5): 1045–50. 2001. doi:10.1006/bbrc.2001.5493. PMID 11527406.
- "Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.". Cancer Res. 61 (19): 7325–32. 2001. PMID 11585773.
- "Differential effect of ik3-1/cables on p53- and p73-induced cell death.". J. Biol. Chem. 277 (4): 2951–7. 2002. doi:10.1074/jbc.M108535200. PMID 11706030.
- "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3).". Eur. J. Biochem. 268 (23): 6076–82. 2002. doi:10.1046/j.0014-2956.2001.02555.x. PMID 11733001.
- "ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl.". Biochim. Biophys. Acta 1574 (2): 157–63. 2002. doi:10.1016/S0167-4781(01)00367-0. PMID 11955625.
- "Loss of cables protein expression in human non-small cell lung cancer: a tissue microarray study.". Hum. Pathol. 34 (2): 143–9. 2003. doi:10.1053/hupa.2003.26. PMID 12612882.
- "Loss of cables, a novel gene on chromosome 18q, in ovarian cancer.". Mod. Pathol. 16 (9): 863–8. 2004. doi:10.1097/01.MP.0000084434.88269.0A. PMID 13679449.
- "ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways.". Biochem. Biophys. Res. Commun. 312 (2): 520–9. 2004. doi:10.1016/j.bbrc.2003.10.142. PMID 14637168.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer.". Cancer Res. 64 (1): 202–8. 2004. doi:10.1158/0008-5472.CAN-03-2833. PMID 14729625.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Aberrant splicing of cables gene, a CDK regulator, in human cancers.". Cancer Biol. Ther. 4 (11): 1211–5. 2006. doi:10.4161/cbt.4.11.2085. PMID 16177568.
- "DNA sequence and analysis of human chromosome 18.". Nature 437 (7058): 551–5. 2005. doi:10.1038/nature03983. PMID 16177791.
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. 2006. doi:10.1038/nbt1240. PMID 16964243.
- "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.". FEBS Lett. 580 (27): 6464–70. 2007. doi:10.1016/j.febslet.2006.10.065. PMID 17101133.
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