Biology:CAMK2D

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Calcium/calmodulin-dependent protein kinase type II delta chain is an enzyme that in humans is encoded by the CAMK2D gene.

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca²⁺/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Four alternatively spliced transcript variants that encode three different isoforms have been characterized to date. Distinct isoforms of this chain have different expression patterns.

Further reading

• "Ca²⁺/CaM-dependent kinases: from activation to function". Annu. Rev. Pharmacol. Toxicol. 41 (1): 471–505. 2001. doi:10.1146/annurev.pharmtox.41.1.471. PMID 11264466. 
• Yamamoto H (2002). "[Molecular mechanisms of the intracellular localizations of Ca²⁺/calmodulin-dependent protein kinase II isoforms, and their physiological functions]". Tanpakushitsu Kakusan Koso 47 (3): 241–7. PMID 11889801. 
• "Multiple and cooperative phosphorylation events regulate the CREM activator function". EMBO J. 12 (10): 3903–11. 1993. doi:10.1002/j.1460-2075.1993.tb06068.x. PMID 8404858. 
• "Identification of novel human tumor cell-specific CaMK-II variants". Biochim. Biophys. Acta 1355 (3): 281–92. 1997. doi:10.1016/S0167-4889(96)00141-3. PMID 9060999. 
• "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): 11832–9. 1997. doi:10.1074/jbc.272.18.11832. PMID 9115241. 
• "Insulinoma cells contain an isoform of Ca²⁺/calmodulin-dependent protein kinase II delta associated with insulin secretion vesicles". Endocrinology 138 (6): 2577–84. 1997. doi:10.1210/endo.138.6.5168. PMID 9165051. 
• "Interaction of the CD5 cytoplasmic domain with the Ca²⁺/calmodulin-dependent kinase IIdelta". Eur. J. Immunol. 28 (7): 2167–77. 1998. doi:10.1002/(SICI)1521-4141(199807)28:07<2167::AID-IMMU2167>3.0.CO;2-L. PMID 9692886. 
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074. 
• "Identification and expression of delta-isoforms of the multifunctional Ca²⁺/calmodulin-dependent protein kinase in failing and nonfailing human myocardium". Circ. Res. 84 (6): 713–21. 1999. doi:10.1161/01.res.84.6.713. PMID 10189359. 
• "Downregulation of delta CaM kinase II in human tumor cells". Biochim. Biophys. Acta 1452 (1): 1–11. 1999. doi:10.1016/S0167-4889(99)00113-5. PMID 10525155. 
• "Cloning and quantitative determination of the human Ca²⁺/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells". Diabetologia 43 (4): 465–73. 2000. doi:10.1007/s001250051330. PMID 10819240. 
• "Activation of Ca²⁺/calmodulin-dependent protein kinase II within post-synaptic dendritic spines of cultured hippocampal neurons". J. Biol. Chem. 275 (35): 27165–71. 2000. doi:10.1074/jbc.M003751200. PMID 10852918. 
• "Requirement of Ca²⁺ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 5971–6. 2002. doi:10.1073/pnas.052159099. PMID 11972023. Bibcode: 2002PNAS...99.5971N. 
• "The S18 ribosomal protein is a putative substrate for Ca²⁺/calmodulin-activated protein kinase II". J. Biol. Chem. 277 (37): 33537–40. 2002. doi:10.1074/jbc.C200342200. PMID 12145273. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca²⁺-calmodulin-dependent protein kinase II". J. Biol. Chem. 279 (13): 12484–94. 2004. doi:10.1074/jbc.M313597200. PMID 14722083. 
• "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics 3 (11): 1093–101. 2005. doi:10.1074/mcp.M400085-MCP200. PMID 15345747. 

External links

• Human CAMK2D genome location and CAMK2D gene details page in the UCSC Genome Browser.