Biology:CAPRIN2
 Generic protein structure example |
caprin family member 2, also known as CAPRIN2, is a human gene.[1]
The protein encoded by this gene may be involved in the transitioning of erythroblasts from a highly proliferative state to a terminal phase of differentiation. High level expression of the encoded protein can lead to apoptosis. Several transcript variants encoding different isoforms have been found for this gene.[1]
Model organisms
| Characteristic | Phenotype |
|---|---|
| Homozygote viability | Normal |
| Fertility | Normal |
| Body weight | Normal |
| Anxiety | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Hot plate | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Body temperature | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology | Normal |
| Peripheral blood lymphocytes | Normal |
| Micronucleus test | Normal |
| Heart weight | Normal |
| Eye Histopathology | Normal |
| Citrobacter infection | Normal[2] |
| All tests and analysis from[3][4] |
Model organisms have been used in the study of CAPRIN2 function. A conditional knockout mouse line, called Caprin2tm1a(EUCOMM)Wtsi[5][6] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[7][8][9]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[3][10] Twenty two tests were carried out on mutant mice, however no significant abnormalities were observed.[3]
References
- ↑ 1.0 1.1 "Entrez Gene: caprin family member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=65981. Retrieved 2011-08-30.
- ↑ "Citrobacter infection data for Caprin2". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MAXJ/citrobacter-challenge/.
- ↑ 3.0 3.1 3.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
- ↑ "International Knockout Mouse Consortium". http://www.knockoutmouse.org/martsearch/search?query=Caprin2.
- ↑ "Mouse Genome Informatics". http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4432518.
- ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M. et al. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMID 21677750.
- ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
- ↑ "A mouse for all reasons". Cell 128 (1): 9–13. January 2007. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. 2011. doi:10.1186/gb-2011-12-6-224. PMID 21722353.
External links
- Human CAPRIN2 genome location and CAPRIN2 gene details page in the UCSC Genome Browser.
Further reading
- "Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth.". J. Biol. Chem. 279 (3): 1916–21. 2004. doi:10.1074/jbc.M305634200. PMID 14593112.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain.". J. Biol. Chem. 285 (31): 24260–9. 2010. doi:10.1074/jbc.M110.108944. PMID 20516077.
- "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.". Nat. Methods 2 (8): 591–8. 2005. doi:10.1038/nmeth776. PMID 16094384.
- "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. 2001. doi:10.1093/dnares/8.2.85. PMID 11347906.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932.
- "Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation.". J. Cell Biol. 182 (5): 865–72. 2008. doi:10.1083/jcb.200803147. PMID 18762581.
- "Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins.". J. Immunol. 172 (4): 2389–400. 2004. doi:10.4049/jimmunol.172.4.2389. PMID 14764709.
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