Biology:CBR3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Carbonyl reductase [NADPH] 3 is an enzyme that in humans is encoded by the CBR3 gene.[1][2][3]
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.[3]
References
- ↑ "Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2". Genomics 52 (1): 95–100. May 1999. doi:10.1006/geno.1998.5380. PMID 9740676.
- ↑ "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact 178 (1–3): 94–8. Feb 2009. doi:10.1016/j.cbi.2008.10.040. PMID 19027726.
- ↑ 3.0 3.1 "Entrez Gene: CBR3 carbonyl reductase 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=874.
External links
- Human CBR3 genome location and CBR3 gene details page in the UCSC Genome Browser.
Further reading
- "Cloning and expression of carbonyl reductase from rat testis.". Eur. J. Biochem. 228 (2): 473–9. 1995. doi:10.1111/j.1432-1033.1995.tb20286.x. PMID 7705364.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.". Genomics 48 (1): 12–23. 1998. doi:10.1006/geno.1997.5146. PMID 9503011.
- "Carbonyl reductase: a novel metastasis-modulating function.". Cancer Res. 60 (5): 1173–6. 2000. PMID 10728668.
- "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. 2000. doi:10.1038/35012518. PMID 10830953. Bibcode: 2000Natur.405..311H.
- "Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer.". Br. J. Cancer 85 (7): 1032–6. 2001. doi:10.1038/sj.bjc.6692034. PMID 11592776.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3).". Drug Metab. Dispos. 33 (2): 254–7. 2005. doi:10.1124/dmd.104.002006. PMID 15537833.
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