Biology:CDC14B

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene.[1][2]

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. Specifically, it is thought to fulfil this role by bundling and stabilising microtubules. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in 3 transcript variants encoding distinct isoforms.[2]

Interactions and Functions

CDC14B has been shown to interact with p53, potentially de-phosphorylate p53 at Serine 315 and thereby stabilize p53.[3] S315-phosphorylated p53, in contrast to other p53 phosphorylation, was shown to facilitate p53 degradation.[4] At the patho-physiological level, mice with CDC14B deletion were shown to exhibit early-onset ageing phenotypes. [5]

References

  1. ↑ "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast". The Journal of Biological Chemistry 272 (47): 29403–29406. November 1997. doi:10.1074/jbc.272.47.29403. PMID 9367992. 
  2. ↑ 2.0 2.1 "Entrez Gene: CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8555. 
  3. ↑ "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". The Journal of Biological Chemistry 275 (4): 2410–2414. January 2000. doi:10.1074/jbc.275.4.2410. PMID 10644693. 
  4. ↑ Li, Y; Cui K; Zhang Q; Li X; Lin X; Tang Y; Prochownik E; Li Y (July 2021). "FBXL6 degrades phosphorylated p53 to promote tumor growth". Cell Death Differ. 28 (7): 2112–2125. doi:10.1038/s41418-021-00739-6. ISSN 1350-9047. PMID 33568778. 
  5. ↑ "Early-onset aging and defective DNA damage response in Cdc14b-deficient mice". Mol. Cell. Biol. 31 (7): 1470–1477. April 2011. doi:10.1128/MCB.01330-10. PMID 21262768. 

Further reading

External links




Retrieved from "https://handwiki.org/wiki/index.php?title=Biology:CDC14B&oldid=2731687"