Biology:CDK5R1

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Cyclin-dependent kinase 5 activator 1 is an enzyme that in humans is encoded by the CDK5R1 gene.[1][2]

Function

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.[2]

In melanocytic cells CDK5R1 gene expression may be regulated by MITF.[3]

Interactions

CDK5R1 has been shown to interact with:

See also

References

  1. "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5". Nature 371 (6496): 419–23. October 1994. doi:10.1038/371419a0. PMID 8090221. Bibcode1994Natur.371..419T. 
  2. 2.0 2.1 "Entrez Gene: CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8851. 
  3. "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. 2008. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  4. "Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35". J. Biol. Chem. 277 (35): 31988–93. August 2002. doi:10.1074/jbc.M201161200. PMID 12084709. 
  5. "Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2". J. Biol. Chem. 276 (11): 8104–10. March 2001. doi:10.1074/jbc.M008932200. PMID 11113134. 
  6. "p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction". Eur. J. Neurosci. 13 (2): 241–7. January 2001. doi:10.1046/j.1460-9568.2001.01376.x. PMID 11168528. 
  7. "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". J. Neurosci. 22 (18): 7879–91. September 2002. doi:10.1523/JNEUROSCI.22-18-07879.2002. PMID 12223541. 
  8. "Identification of a common protein association region in the neuronal Cdk5 activator". J. Biol. Chem. 275 (41): 31763–9. October 2000. doi:10.1074/jbc.M004358200. PMID 10915792. 
  9. "Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation". Blood 97 (12): 3763–7. June 2001. doi:10.1182/blood.V97.12.3763. PMID 11389014. 
  10. "Structure and regulation of the CDK5-p25(nck5a) complex". Mol. Cell 8 (3): 657–69. September 2001. doi:10.1016/S1097-2765(01)00343-4. PMID 11583627. 
  11. "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". J. Biol. Chem. 277 (9): 7324–32. March 2002. doi:10.1074/jbc.M107270200. PMID 11741927. 

Further reading

External links