Biology:CDKL2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene.[1][2]
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus.[2]
References
- ↑ "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE". Oncogene 13 (12): 2563–74. Feb 1997. PMID 9000130.
- ↑ 2.0 2.1 "Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8999.
External links
- Human CDKL2 genome location and CDKL2 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: Q92772 (Cyclin-dependent kinase-like 2) at the PDBe-KB.
Further reading
- Marracci GH; Marquardt WE; Strehlow A et al. (2006). "Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck)". Biochem. Biophys. Res. Commun. 344 (3): 963–971. doi:10.1016/j.bbrc.2006.03.172. PMID 16631599.
- Sarkar SN; Peters KL; Elco CP et al. (2004). "Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling". Nat. Struct. Mol. Biol. 11 (11): 1060–1067. doi:10.1038/nsmb847. PMID 15502848.
- Tao J; Van Esch H; Hagedorn-Greiwe M et al. (2005). "Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation". Am. J. Hum. Genet. 75 (6): 1149–1154. doi:10.1086/426460. PMID 15499549.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMID 15489334.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- "Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors". J. Biol. Chem. 270 (16): 9115–9120. 1995. doi:10.1074/jbc.270.16.9115. PMID 7721825.
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