Biology:CEP192
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene.[1][2] It is the homolog of the C. elegans and D. melanogaster gene SPD-2.[3]
Cep192 is a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells.[3] It stimulates the formation of the scaffolding upon which gamma tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis.[4]
References
- ↑ "Entrez Gene: centrosomal protein 192kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55125.
- ↑ "Proteomic characterization of the human centrosome by protein correlation profiling". Nature 426 (6966): 570–4. December 2003. doi:10.1038/nature02166. PMID 14654843. Bibcode: 2003Natur.426..570A.
- ↑ 3.0 3.1 Zhu, F.; Lawo, S.; Bird, A.; Pinchev, D.; Ralph, A.; Richter, C.; Müller-Reichert, T.; Kittler, R. et al. (2008). "The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis". Current Biology 18 (2): 136–141. doi:10.1016/j.cub.2007.12.055. PMID 18207742.
- ↑ Gomez-Ferreria, M.; Rath, U.; Buster, D.; Chanda, S.; Caldwell, J.; Rines, D.; Sharp, D. (2007). "Human Cep192 is required for mitotic centrosome and spindle assembly". Current Biology 17 (22): 1960–1966. doi:10.1016/j.cub.2007.10.019. PMID 17980596.
External links
- Human CEP192 genome location and CEP192 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: Q8TEP8 (Centrosomal protein of 192 kDa) at the PDBe-KB.
Further reading
- "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. 2000. doi:10.1093/dnares/7.4.271. PMID 10997877.
- "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function". J. Cell Biol. 129 (6): 1617–28. 1995. doi:10.1083/jcb.129.6.1617. PMID 7790358.
- "The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis". Curr. Biol. 18 (2): 136–41. 2008. doi:10.1016/j.cub.2007.12.055. PMID 18207742.
- "Human Cep192 is required for mitotic centrosome and spindle assembly". Curr. Biol. 17 (22): 1960–6. 2007. doi:10.1016/j.cub.2007.10.019. PMID 17980596.
- "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837–46. 2000. doi:10.1083/jcb.151.4.837. PMID 11076968.
- "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Defining the Human Deubiquitinating Enzyme Interaction Landscape". Cell 138 (2): 389–403. 2009. doi:10.1016/j.cell.2009.04.042. PMID 19615732.
- "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell 13 (9): 3235–45. 2002. doi:10.1091/mbc.E02-02-0112. PMID 12221128.
- "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Dev. Cell 5 (1): 113–25. 2003. doi:10.1016/S1534-5807(03)00193-X. PMID 12852856.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation". EMBO Rep. 7 (4): 418–24. 2006. doi:10.1038/sj.embor.7400639. PMID 16462731.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. 2005. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
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