Biology:CHAF1B
From HandWiki
Short description: Protein-coding gene in humans
 Generic protein structure example |
Chromatin assembly factor 1 subunit B is a protein that in humans is encoded by the CHAF1B gene.[1][2][3]
Function
Chromatin assembly factor I (CAF-1) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair.[3]
Interactions
CHAF1B has been shown to interact with:
References
- ↑ "The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication". Cell 81 (7): 1105–14. Jun 1995. doi:10.1016/S0092-8674(05)80015-7. PMID 7600578.
- ↑ "The gene encoding the p60 subunit of chromatin assembly factor I (CAF1P60) maps to human chromosome 21q22.2, a region associated with some of the major features of Down syndrome". Human Genetics 98 (4): 497–9. Oct 1996. doi:10.1007/s004390050246. PMID 8792829.
- ↑ 3.0 3.1 "Entrez Gene: CHAF1B chromatin assembly factor 1, subunit B (p60)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8208.
- ↑ 4.0 4.1 "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports 3 (4): 329–34. Apr 2002. doi:10.1093/embo-reports/kvf068. PMID 11897662.
- ↑ "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3. 2007. doi:10.1038/msb4100134. PMID 17353931.
- ↑ "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell 113 (7): 905–17. Jun 2003. doi:10.1016/s0092-8674(03)00436-7. PMID 12837248.
Further reading
- "CAF-1 and the inheritance of chromatin states: at the crossroads of DNA replication and repair". Journal of Cell Science 113 (15): 2647–58. Aug 2000. doi:10.1242/jcs.113.15.2647. PMID 10893180.
- "Mapping of the gene for the p60 subunit of the human chromatin assembly factor (CAF1A) to the Down syndrome region of chromosome 21". Genomics 33 (2): 309–12. Apr 1996. doi:10.1006/geno.1996.0199. PMID 8660983.
- "Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4". Cell 87 (1): 95–104. Oct 1996. doi:10.1016/S0092-8674(00)81326-4. PMID 8858152.
- "Identification of novel M phase phosphoproteins by expression cloning". Molecular Biology of the Cell 7 (9): 1455–69. Sep 1996. doi:10.1091/mbc.7.9.1455. PMID 8885239.
- "Nucleosome assembly activity and intracellular localization of human CAF-1 changes during the cell division cycle". The Journal of Biological Chemistry 273 (24): 15279–86. Jun 1998. doi:10.1074/jbc.273.24.15279. PMID 9614144.
- "Recruitment of phosphorylated chromatin assembly factor 1 to chromatin after UV irradiation of human cells". The Journal of Cell Biology 143 (3): 563–75. Nov 1998. doi:10.1083/jcb.143.3.563. PMID 9813080.
- "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. May 2000. doi:10.1038/35012518. PMID 10830953. Bibcode: 2000Natur.405..311H.
- "Requirement of Cyclin/Cdk2 and protein phosphatase 1 activity for chromatin assembly factor 1-dependent chromatin assembly during DNA synthesis". The Journal of Biological Chemistry 275 (45): 35512–21. Nov 2000. doi:10.1074/jbc.M003073200. PMID 10938080.
- "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports 3 (4): 329–34. Apr 2002. doi:10.1093/embo-reports/kvf068. PMID 11897662.
- "BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms". Journal of Cell Science 116 (Pt 14): 2929–36. Jul 2003. doi:10.1242/jcs.00480. PMID 12771185.
- "Silencing of chromatin assembly factor 1 in human cells leads to cell death and loss of chromatin assembly during DNA synthesis". Molecular and Cellular Biology 24 (7): 2853–62. Apr 2004. doi:10.1128/MCB.24.7.2853-2862.2004. PMID 15024074.
- "Reduction of chromatin assembly factor 1 p60 and C21orf2 protein, encoded on chromosome 21, in Down Syndrome brain". Advances in Down Syndrome Research. Journal of Neural Transmission Supplement 67. 67. 2003. 117–28. doi:10.1007/978-3-7091-6721-2_10. ISBN 978-3-211-40776-9.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. Aug 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Molecular and Cellular Biology 24 (20): 9176–85. Oct 2004. doi:10.1128/MCB.24.20.9176-9185.2004. PMID 15456888.
- "Human Asf1 regulates the flow of S phase histones during replicational stress". Molecular Cell 17 (2): 301–11. Jan 2005. doi:10.1016/j.molcel.2004.12.018. PMID 15664198.
External links
- Human CHAF1B genome location and CHAF1B gene details page in the UCSC Genome Browser.
- Human MPP7 genome location and MPP7 gene details page in the UCSC Genome Browser.
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