Biology:CHD3
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Chromodomain-helicase-DNA-binding protein 3 is an enzyme that in humans is encoded by the CHD3 gene.[1][2][3]
Function
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.[3]
Mutations in CHD3 cause a neurodevelopmental syndrome (Snijders Blok-Campeau syndrome) with macrocephaly and impaired speech and language.[4]
Interactions
CHD3 has been shown to interact with:
References
- ↑ "Characterization of the CHD family of proteins". Proceedings of the National Academy of Sciences of the United States of America 94 (21): 11472–7. Oct 1997. doi:10.1073/pnas.94.21.11472. PMID 9326634. Bibcode: 1997PNAS...9411472W.
- ↑ "Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen". The Journal of Clinical Investigation 96 (4): 1730–7. Oct 1995. doi:10.1172/JCI118218. PMID 7560064.
- ↑ 3.0 3.1 "Entrez Gene: CHD3 chromodomain helicase DNA binding protein 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1107.
- ↑ "CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language". Nature Communications 9 (1): 4619. November 2018. doi:10.1038/s41467-018-06014-6. PMID 30397230. Bibcode: 2018NatCo...9.4619S.
- ↑ 5.0 5.1 "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature 395 (6705): 917–21. Oct 1998. doi:10.1038/27699. PMID 9804427. Bibcode: 1998Natur.395..917T.
- ↑ "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology 22 (3): 835–48. Feb 2002. doi:10.1128/mcb.22.3.835-848.2002. PMID 11784859.
- ↑ "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry 278 (9): 7234–9. Feb 2003. doi:10.1074/jbc.M208992200. PMID 12493763.
- ↑ "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature 418 (6901): 994–8. Aug 2002. doi:10.1038/nature01024. PMID 12198550. Bibcode: 2002Natur.418..994H.
- ↑ "Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3". FEBS Letters 533 (1–3): 14–20. Jan 2003. doi:10.1016/s0014-5793(02)03737-7. PMID 12505151.
- ↑ "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. Sep 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
External links
- Human CHD3 genome location and CHD3 gene details page in the UCSC Genome Browser.
Further reading
- "Mi-2/NuRD: multiple complexes for many purposes". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1677 (1–3): 52–7. Mar 2004. doi:10.1016/j.bbaexp.2003.10.010. PMID 15020045.
- "Expressed sequence tags and chromosomal localization of cDNA clones from a subtracted retinal pigment epithelium library". Genomics 13 (3): 873–6. Jul 1992. doi:10.1016/0888-7543(92)90173-P. PMID 1639417. https://deepblue.lib.umich.edu/bitstream/2027.42/29973/1/0000336.pdf.
- "The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation". Arthritis and Rheumatism 38 (10): 1389–99. Oct 1995. doi:10.1002/art.1780381006. PMID 7575689.
- "Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen". Arthritis and Rheumatism 39 (10): 1769–71. Oct 1996. doi:10.1002/art.1780391029. PMID 8843877.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. Sep 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Identification of a human 17p-located cDNA encoding a protein of the Snf2-like helicase family". European Journal of Biochemistry 254 (3): 558–64. Jun 1998. doi:10.1046/j.1432-1327.1998.2540558.x. PMID 9688266.
- "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature 395 (6705): 917–21. Oct 1998. doi:10.1038/27699. PMID 9804427. Bibcode: 1998Natur.395..917T.
- "CCG repeats in cDNAs from human brain". Human Genetics 103 (6): 666–73. Dec 1998. doi:10.1007/s004390050889. PMID 9921901.
- "Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes". Immunity 10 (3): 345–55. Mar 1999. doi:10.1016/S1074-7613(00)80034-5. PMID 10204490.
- "Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation". Nature Genetics 23 (1): 62–6. Sep 1999. doi:10.1038/12664. PMID 10471500.
- "Physical map of 17p13 and the genes adjacent to p53". Genomics 63 (1): 60–8. Jan 2000. doi:10.1006/geno.1999.6062. PMID 10662545.
- "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif". The Journal of Biological Chemistry 275 (46): 36316–23. Nov 2000. doi:10.1074/jbc.M004293200. PMID 10961991.
- "Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD". Genes & Development 15 (4): 428–43. Feb 2001. doi:10.1101/gad.869501. PMID 11230151.
- "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature 419 (6907): 641–5. Oct 2002. doi:10.1038/nature01084. PMID 12374985. Bibcode: 2002Natur.419..641Y. https://digital.library.unt.edu/ark:/67531/metadc733622/.
- "Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3". FEBS Letters 533 (1–3): 14–20. Jan 2003. doi:10.1016/S0014-5793(02)03737-7. PMID 12505151.
- "MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer". Cell 113 (2): 207–19. Apr 2003. doi:10.1016/S0092-8674(03)00234-4. PMID 12705869.
- "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Research 98 (1): 83–91. Dec 2003. doi:10.1016/j.virusres.2003.09.001. PMID 14609633.
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